Dr. Shieh, Sheau-Yann 謝小燕 博士

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Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress.

Oncogene, Mar 30, 2009

Human checkpoint kinase 1 (CHK1) is an essential kinase required to preserve genome stability, and is activated by DNA replication blockage through the ataxia-telangiectasia-mutated-and-Rad3-related (ATR)/ATRIP-signaling pathway.

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