Dr. Shieh, Sheau-Yann 謝小燕 博士

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p53-Mediated transactivation of LIMK2b links actin dynamics to cell cycle checkpoint control.

Oncogene, Mar 01, 2010

The p53 tumor suppressor protein is widely known for its role as a sequence-specific transcription factor that regulates the expression of stress response genes. Here, we report the identification of LIMK2, which encodes a kinase that regulates actin dynamics through phosphorylation of cofilin, as a p53 target upregulated by DNA damage.

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