Dr. Hsieh, Patrick Ching-Ho 謝清河 博士

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Functionalized Nanoparticles Provide Early Cardioprotection after Acute Myocardial Infarction.

J Control Release, May 09, 2013

Recent developments in nanotechnology have created considerable potential toward diagnosis and cancer therapy. In contrast, the use of nanotechnology in tissue repair or regeneration remains largely unexplored. We hypothesized that intramyocardial injection of insulin-like growth factor (IGF)-1-complexed poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles (PLGA-IGF-1 NPs) increases IGF-1 retention, induces Akt phosphorylation, and provides early cardioprotection after acute myocardial infarction (MI).

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