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Dr. Lim, Carmay

Emeritus Research Fellow
  • +886-2-2789-9043 (Lab) (Room No: N117)
  • +886-2-2652-3031 (Office)
  • +886-2-2788-7641 (Fax)
Specialty:
  • Computational Biophysics
  • Computational Chemistry
  • Bioinformatics
Education and Positions:

  • 1984, Ph.D. in Chemical Physics, University of Minnesota, Minneapolis

    1979, B.S. in Chemistry, Royal Holloway College, London University

     

My long–term research philosophy/interests are (1) to unravel the underlying physico–chemical principles governing biological processes and use them to guide the design of molecules with potential practical/therapeutic utility, and (2) to develop new methods for studying macromolecular systems. Our current research is focused in the following three areas:

1. Protein Binding and Folding: this involves a systematic study of the individual forces governing protein-cofactor, protein-protein and protein-nucleic acid binding affinity and specificity.

2. Structure-Based Rational Drug Design: our focus is on the structure-based rational design of antibiotics and antibody-based therapeutics.

3. New Algorithms and Theory: we are developing new methods to predict various binding sites and protein interaction partners as well as implicit solvent models for molecular dynamics/docking simulations.

A variety of computational methods are employed including ab initio quantum mechanics methods, molecular dynamics/free energy simulations, continuum dielectric methods, solvation theory, protein docking, homology modeling, and database mining. The above research in bioinformatics, computational biophysics and computational chemistry is at the interface of biology, physics, chemistry, and computer science, thus students will develop interdisciplinary knowledge and skills.

Our Team
Team photo

Journal 155 Book 1

  1. Karen Sargsyan*, Karine Mazmanian*, (Carmay Lim)* A 2023: to small molecule drugs and application to SARS-CoV-2 SCIENTIFIC REPORTS 13, 502 (2023) [JCR] [WOS]
  2. Sahana Shankar, Zi-Ting Hsu, Artur Ezquerra, Chien-Chien Li, Tzu-Lun Huang, Etienne Coyaud, Cédric Grauffel, Brian Raught, Carmay Lim, Jens Lüders*, Su-Yi Tsai*, and Kuo-Chiang Hsia* A g-tubulin complex-dependent pathway suppresses unscheduled ciliogenensis by promoting cilia disassembly Cell Reports 41, 111642 (2022-11-15) [JCR] [WOS]
  3. Cédric Grauffel*, Wei-Hsiang Weng, (Carmay Lim*) Factors Allowing Small Monovalent Li+ to Displace Ca2+ in Proteins Phys. Chem. Chem. Phys. 24, 17759 (2022-07-05) [JCR] [WOS]
  4. Wen-Hao Tsai (蔡文豪), Cédric Grauffel, Ming-Yueh Huang (黃名鉞), Sandra Postić, Marjan Slak Rupnik, Carmay Lim (林小喬), Shi-Bing Yang (楊世斌)* Allosteric coupling between TM4 and selectivity filter regulates extracellular pH gating of TALK1 potassium channels J. Biol.Chem. 298, 101998 (2022-04-29) [JCR] [WOS]
  5. Ting Chen, Cédric Grauffel, Wei-Zen Yang, Yi-Ping Chen, Hanna S. Yuan* and (Carmay Lim*) Efficient strategy to design protease inhibitors: Application to enterovirus 71 2A protease ACS Bio & Med Chem Au 4, 437-449 (2022-04-19) [JCR] [WOS]
  6. Karine Mazmanian, Ting Chen, Karen Sargsyan, & Carmay Lim* From quantum-derived principles underlying cysteine reactivity to combating the COVID-19 pandemic WIRES Computational Molecular Science 12, e1607 (2022-02-13) [JCR] [WOS]
  7. Yao Chi Chen*, Yu-Hsien Chen, Jon D. Wright, and (Carmay Lim*) PPI-HotspotDB: Database of Protein!Protein Interaction Hot Spots J. Chem. Inf. Model. 62, 1052-1060 (2022-02-11) [JCR] [WOS]
  8. Todor Dudev,* Cedric Grauffel,* and (Carmay Lim*) Calcium in signaling: Its specificity and vulnerabilities towards biogenic and abiogenic metal ions. The Journal of Physical Chemistry B 125,37, 10419-10431 (2021-09) [JCR] [WOS]
  9. Cédric Grauffel*, Wei-Hsiang Weng, Todor Dudev,(Carmay Lim*) The trinuclear calcium site in the C2 domain of PKCα/γis prone to lithium attack. ACS Omega 6,31, 20657-20666 (2021-07) [JCR] [WOS]
  10. Babu C. Satheesan, Lim Carmay Influence of solution ionic strength on the stabilities of M20 loop conformations in apo E. coli dihydrofolate reductase The Journal of Chemical Physics 154(19), 195103 (2021-05) [JCR] [WOS]
- More Publications-

- POSTDOC -
Babu, C. Satheesan
Babu, C. Satheesan
Wright, Jon
Wright, Jon
Grauffel, Cédric
Grauffel, Cédric
Lee, Yu-Ming (Leon)
Lee, Yu-Ming (Leon)
Chen, Ting （Cindy）
Chen, Ting （Cindy）
Sargsyan, Karen
Sargsyan, Karen
Mazmanian, Karine
Mazmanian, Karine
Chen, Yao Chi (Backy)
Chen, Yao Chi (Backy)
- RESEARCH ASSOCIATES -
Chen, Yu-Hsien (Jackie)
Chen, Yu-Hsien (Jackie)
Tseng, Yun Ting (Mary)
Tseng, Yun Ting (Mary)