Dr. Lin, Teng-Nan 's publons link picture

Dr. Lin, Teng-Nan

Adjunct Research Fellow
  • 886-2-2789-9141 (Lab) (Room No: 404)
  • 2652-3936 (Office)
  • 2785-8847 (Fax)
Specialty:
  • Cerebral Ischemia
  • Angiogenesis
  • Neurochemistry
Education and Positions:

  • Ph.D. in Biochemistry, Univ. of Missouri-Columbia.

Stroke or brain attack is the third leading cause of death and the leading cause of adult disability worldwide. Unfortunately, besides the tPA, no other treatment is available to limit brain damage. Because of the prevalence and seriousness of this disorder, there is a great need for intervention.

The major goal of our research is to unravel the cellular and molecular mechanisms underlying neuronal injury and recovery following ischemia-reperfusion. Our recent study demonstrates angiogenesis is a plausible therapeutic regimen to combat cerebrovascular diseases. Taken our study for example, ectopically expression of cyclooxygenase-1 (COX-1) augments the level of angiogenic factor PGI2 that subsequently activates Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) and then reduces inflammation against ischemic stroke. PPAR-γ confers resistance to neuronal apoptosis and cerebral infarction by driving 14-3-3ε transcription. Upregulation of 14-3-3εenhances sequestration of phosphorylated Bad, thereby suppressing apoptosis. PPAR-γ can also inhibit ischemia-induced Bcl-2/Bcl-xl degradation and formation of ROS and ROS-related genes, leading to enhance neuronal survival.

We recently branch to study the effect of herbal medicine on ischemic brain injury. We reported that the extract of C. nutans mitigates neuronal death and reduces ischemic brain injury by activating PPAR-r while downregulating HDACs. As quoted from Louis Pasteur: "When meditating over a disease, I never think of finding a remedy for it, but instead a means of preventing it."   \\\\

Our Team
Team photo

Journal 70 Book 5

  1. Farooqui AA, Farooqui T, Sun GY, (Lin TN), Teh DBL, Ong WY* COVID-19, Blood Lipid Changes, and Thrombosis. Biomedicines 11(4), 1181-1189 (2023-04) [JCR] [WOS]
  2. Kao MH, Huang CY, Cheung WM, Yan YT, Chen JJ, Ho YS, Hsu CY, (Lin TN)* Activating Transcription Factor 3 Diminishes Ischemic Cerebral Infarct and Behavioral Deficit by Downregulating Carboxyl-Terminal Modulator Protein. International journal of molecular sciences 24(3), 2306-2306 (2023-02) [JCR] [WOS]
  3. Ong WY, Kao MH, Cheung WM, Leow DM, Cheah IK, (Lin TN)* Protective Effect of Ergothioneine Against Stroke in Rodent Models. Neuromolecular medicine Online first, 1-11 (2022-10) [JCR] [WOS]
  4. Ong WY, Herr DR, Sun GY, (Lin TN) Anti-Inflammatory Effects of Phytochemical Components of Clinacanthus nutans. Molecules (Basel, Switzerland) 27(11), 3607 (2022-06) [JCR] [WOS]
  5. Kao MH, Wu JS, Cheung WM, Chen JJ, Sun GY, Ong WY, Herr DR, (Lin TN*) Clinacanthus nutans Mitigates Neuronal Death and Reduces Ischemic Brain Injury: Role of NF-kappaB-driven IL-1beta Transcription. Neuromolecular medicine 23(1), 199-210 (2021-01) [JCR] [WOS]
  6. Chen HL, Lo CH, Huang CC, Lu MP, Hu PY, Chen CS, Chueh DY, Chen P, (Lin TN), Lo YH, Hsiao YP, Hsu DK, Liu FT Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis. The Journal of clinical investigation 131(1), 1-10 (2021-01) [JCR] [WOS]
  7. Wu KH, Lee WJ, Cheng TC, Chang HW, Chen LC, Chen CC, Lien HM*, (Lin TN)*, Ho YS* Study of the antitumor mechanisms of apiole derivatives (AP-02) from Petroselinum crispum through induction of G0/G1 phase cell cycle arrest in human COLO 205 cancer cells. BMC complementary and alternative medicine 19(1), 188 (2019-07) [JCR] [WOS]
  8. Kao MH, (Lin TN)* Histone deacetylases in stroke. The Chinese journal of physiology 62(3), 95-107 (2019-05-06) [JCR] [WOS]
  9. Wu JS, Kao MH, Tsai HD, Cheung WM, Chen JJ, Ong WY, Sun GY, (Lin TN*) Clinacanthus nutans Mitigates Neuronal Apoptosis and Ischemic Brain Damage Through Augmenting the C/EBPbeta-Driven PPAR-gamma Transcription. Molecular neurobiology 55(7), 5425-5438 (2018) [JCR] [WOS]
  10. Ho CF, Bon CP, Ng YK, Herr DR, Wu JS, (Lin TN), Ong WY* Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells. Neurochemical research 43(3), 540-555 (2018) [JCR] [WOS]
- More Publications-

- RESEARCH ASSOCIATES -
Cheung, Wai Mui
Cheung, Wai Mui
Huang, Ting-Yi
Huang, Ting-Yi
Lai, Ming-Syun
Lai, Ming-Syun
- STUDENTS -
Kao, Mei-Han
Kao, Mei-Han
- ALUMNI -
Wu, Jui Sheng
Wu, Jui Sheng
Tsai, Hsin Da
Tsai, Hsin Da
Pan, Yi Ting
Pan, Yi Ting