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Dr. Lin, Wen-chang

Research Fellow
  • 02-27899148 (Lab) (Room No: N601)
  • 02-26523967 (Office)
  • 02-27827654 (Fax)
Specialty:
  • Bioinformatics and databases
  • Tumor Biology and cancer biomarkers
  • miRNA and protein-coding gene discovery
Education and Positions:

  • Ph.D. Case Western Reserve University

     

The long-term research goal of our laboratory is to utilize bioinformatic tools/databases in elucidating molecular and cellular aspects of functional transcription elements in human genome and their significance in oncogenesis and tumor progression. These functional transcription elements include traditional protein-coding genes and non-coding ones. Our research efforts are intended to elucidate functions and regulations of these transcription elements using bioinformatics data-mining and molecular experimental approaches. Previously, we have used the dbEST database for the discovery of novel human genes, identification of functional nucleotide polymorphisms (SNPs and InDels). Subsequently, we further discover and interrogate a new wobble-splicing mechanism at exon junctions that results in the generation of InDel variants in protein coding transcripts. In order to interrogate the functional aspects of these elements, we have developed gene oriented ortholog assignment and protein domain ortholog classification algorithms and databases. We have also emphasized on the discovery of non-coding regulatory microRNAs. Informatic pipelines are employed to discover and interrogate miRNAs from genomic sequences of viruses, parasites and animals. We have also engaged in the regulation features of human miRNAs in oncogenesis and their cancer biomarker potential in liquid biopsy. There are several bioinformatic databases established in our laboratory:
Virus miRNAs & target prediction service
miRNA clusters
Conserved miRNAs in animal genomes
Protein ortholog discovery by comparative gene identification
Protein ortholog interrogation by domain features
Protein ortholog annotation by genomic loci
Duplicated gene loci variants
Transcript isoforms in human protein-coding genes
Representative Tissue Transcripts of Protein-coding Genes
microRNA Target Visualization Tool for TCGA cancers
Tissue Expression Profiles of MANE-select Transcripts
 
Our Team
Team photo

Journal 121 Book 0

  1. Kao Hsiao-Wei, Tsai Kuo-Wang, Lin Wen-chang Synergistic Effect of Metformin and Lansoprazole Against Gastric Cancer through Growth Inhibition International Journal of Medical Sciences 20(6), 717-724 (2023) [JCR] [WOS]
  2. Yarmishyn AA, Ishola AA, Chen CY, Verusingam ND, Rengganaten V, Mustapha HA, Chuang HK, Teng YC, Phung VL, Hsu PK, Lin WC, Ma HI, Chiou SH, Wang ML Circular RNAs Modulate Cancer Hallmark and Molecular Pathways to Support Cancer Progression and Metastasis. Cancers 14(4), 862 (2022) [JCR] [WOS]
  3. Tung KF, Pan CY, Lin WC Dominant transcript expression profiles of human protein-coding genes interrogated with GTEx dataset. Scientific reports 12(1), 6969 (2022) [JCR] [WOS]
  4. Su PY, Yen SB, Yang CC, Chang CH, Lin WC, Shih C Hepatitis B virus virion secretion is a CRM1-spike-mediated late event. Journal of biomedical science 29(1), 44 (2022) [JCR] [WOS]
  5. Yang YP, Lee AC, Lin LT, Chen YW, Huang PI, Ma HI, Chen YC, Lo WL, Lan YT, Fang WL, Wang CY, Liu YY, Hsu PK, Lin WC, Li CP, Chen MT, Chien CS, Wang ML Strategic Decoy Peptides Interfere with MSI1/AGO2 Interaction to Elicit Tumor Suppression Effects. Cancers 14(3), 505 (2022) [JCR] [WOS]
  6. Tung Kuo-Feng, Lin Wen-chang TEx-MST: tissue expression profiles of MANE select transcripts DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION 2022, baac089 (2022) [JCR] [WOS]
  7. Yang YP, Chien CS, Yarmishyn AA, Chan MS, Lee AC, Chen YW, Huang PI, Ma HI, Lo WL, Chien Y, Lin WC, Wang ML, Chen MT Musashi-1 Regulates MIF1-Mediated M2 Macrophage Polarization in Promoting Glioblastoma Progression. Cancers 13(8), 1799 (2021) [JCR] [WOS]
  8. Chen Chao-Hsin, Tung Kuo-Fong, Lin Wen-Chang Exploration of deep-learning based classification with human SNP image graphs bioRxiv (2021) [JCR] [WOS]
  9. Pan Chao-Yu, Lin Wen-Chang miR-TV: an interactive microRNA Target Viewer for microRNA and target gene expression interrogation for human cancer studies DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION 2020, baz148 (2020) [JCR] [WOS]
  10. Tung Kuo-Feng, Pan Chao-Yu, Chen Chao-Hsin, Lin Wen-chang Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset Scientific Reports 10(1), 16245 (2020) [JCR] [WOS]
- More Publications-

- RESEARCH ASSOCIATES -
Kao, Hsiao-Wei
Kao, Hsiao-Wei
member
Tung, Kuo-Feng
- ALUMNI -
Lu, Tzu-Chiao
Lu, Tzu-Chiao
Tsai, Kuo-Wang
Tsai, Kuo-Wang
Lai, Chun-Hung
Lai, Chun-Hung
Huang, Chia-Lin
Huang, Chia-Lin
member
Pan, Chao-Yu