Dr. Shen, Chen-Yang 沈志陽 博士

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Dr. Shen, Chen-Yang
沈志陽 博士

Distinguished Research Fellow
特聘研究員

  • Ph.D. Univ. of North Carolina at Chapel Hill

  • 02-27899036 (Lab) (Room No: N143)
  • 02-27823047 (Fax)
  • bmcys@ibms.sinica.edu.tw
Specialty:
  • Molecular Epidemiology
  • Cancer Genetics
  • Personalized Medicine

RESEARCH

Cancer development and progression are highly associated with germline or somatically-acquired genomic alterations in tumor. Our attempt to promote the understanding of molecular tumorigenesis of breast cancer comes from this concept, and we explore study questions based on different approaches. Our laboratory is a member of interactional breast cancer consortium, using the genome-wide association study and successfully identifying multiple genomic loci important in determining genetic susceptibility of breast cancer. In 2012, using the next-generation sequencing, scientific community began to explore somatic changes in tumor, and we participated in the international research team, and jointly publish the first exomic sequencing results of breast cancer. Furthermore, viewing the importance of microRNA in regulating physical mechanisms, we combined both genome-wide association study approach and cell-based experiments, resulting in the identification of a novel pathway mediating breast cancer metastasis. We also explore detailed mechanisms underlying DNA damage response and DNA repair, the understanding of which is essential to yield crucial clues to result in effective treatment of cancer.

研究介紹

癌症的發生與進展與基因體先天或後天的變異有絕對必然的相關,我們探討決定乳癌發生與進展的因素便是從此一角度,以不同的研究策略尋找可能的線索。就先天遺傳變異的層面,我們參與國際研究聯盟進行全基因體掃描,找出許多個影響乳癌發生的易感性基因位置,就後天突變層面,我們於2012年參與國際團隊,完成世界第一篇乳癌組織定序的研究。除此之外,考慮到微小RNA對生理病理機制的重要性,我們結合全基因體掃描與基礎研究的結果,發現一個重要調控乳癌轉移的機制,同樣也是基於基因體變異發生對致癌的重要性,基因體修復機制的調控也是我們重要的研究課題。

HIGHLIGHT 重要成果

Detecting Genetic Ancestry and Adaptation in the Taiwanese Han People
Molecular Biology and Evolution, Dec 18, 2020

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