Ph.D. Univ. of North Carolina at Chapel Hill
Cancer development and progression are highly associated with germline or somatically-acquired genomic alterations in tumor. Our attempt to promote the understanding of molecular tumorigenesis of breast cancer comes from this concept, and we explore study questions based on different approaches. Our laboratory is a member of interactional breast cancer consortium, using the genome-wide association study and successfully identifying multiple genomic loci important in determining genetic susceptibility of breast cancer. In 2012, using the next-generation sequencing, scientific community began to explore somatic changes in tumor, and we participated in the international research team, and jointly publish the first exomic sequencing results of breast cancer. Furthermore, viewing the importance of microRNA in regulating physical mechanisms, we combined both genome-wide association study approach and cell-based experiments, resulting in the identification of a novel pathway mediating breast cancer metastasis. We also explore detailed mechanisms underlying DNA damage response and DNA repair, the understanding of which is essential to yield crucial clues to result in effective treatment of cancer.