Dr. Chen, Steve S.-L. 陳士隆 博士
Ph.D., Biochemistry, Purdue University
| 1. | Ke, P.Y., and Chen, S.S.* Autophagy in hepatitis C virus-host interactions: potential roles and therapeutic targets for liver-associated diseases World Journal of Gastroenterology 20(19), 5773-5793 (2014-05) [JCR] [WOS] |
| 2. | Chen, S.S.*, and Ke, P.Y. Suppression of innate antiviral immunity after hepatitis C virus infection: role of the unfolded protein response and autophagy (review) Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging Volume 2 - Role In General Diseases. Pages 137-159. Elsevier Publishing Company, London, UK (2014-01) [JCR] [WOS] |
| 3. | Chen, S.S.*, and Ke, P.Y. Suppression of innate antiviral immunity after hepatitis C virus infection: role of the unfolded protein response and autophagy Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, and Infection. (Four-volume series) (2013-05-01) [JCR] [WOS] |
| 4. | Ke, P.Y., and Chen, S.S.* Active RNA replication of hepatitis C virus downregulates CD81 expression PLoS One 8(1), e54866 (2013-01) [JCR] [WOS] |
| 5. | Ke, P.Y., and Chen, S.S.* Multifaceted roles of autophagy in the life cycle of Flaviviridae Recent Research Developments in Virology-8th issue (2012-12) [JCR] [WOS] |
| 6. | Ke, P.Y., and Chen, S.S.* Multifaceted roles of autophagy in the life cycle of Flaviviridae (review) Recent Research Developments in Virology-volume 8 Page 1-22. Transworld Research Network. Kerala, India (2012-12) [JCR] [WOS] |
| 7. | Ke, P.Y. and Chen, S.S.* Hepatitis C virus and cellular stress response: implications to molecular pathogenesis of liver diseases (review) Viruses-Basel 4(10), 2251-2290 (2012-10) [JCR] [WOS] |
| 8. | Klionsky D.J. and 1268 others (Chen, S.S. is an author) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes Autophagy 8(4), 445-544 (2012-04) [JCR] [WOS] |
| 9. | Lee JW, Liao PC, Young KC, Chang CL, Chen SS, Chang TT, Lai MD, Wang SW* Identification of hnRNPH1, NF45, and C14orf166 as Novel Host Interacting Partners of the Mature Hepatitis C Virus Core Protein. JOURNAL OF PROTEOME RESEARCH 10(10), 4522-4534 (2011-10) [JCR] [WOS] |
| 10. | Ke, P.Y., and Chen, S.S. Emergence of a host cellular restriction mechanism on propagation of hepatitis virus. 18th International Symposium on hepatitis C virus and Related Viruses (2011-09) [JCR] [WOS] |
| 11. | Chang CC, Cheng SF, Lin CH, Chen SS, Chang DK* Stability of gp41 hairpin and helix bundle assembly probed by combined stacking and circular dichroic approaches. Journal of structural biology 175(3), 406-414 (2011-09) [JCR] [WOS] |
| 12. | Chen, S.S., and Ke, Po.-Y Stable growth of hepatitis C virus in cell culture: revelation of emergence of superinfection exclusion in HCV highly replicating cells XV International Congress of Virology (2011-09) [JCR] [WOS] |
| 13. | Ke PY, Chen SS* Autophagy: A novel guardian of HCV against innate immune response. Autophagy 7(5), 533-535 (2011-05) [JCR] [WOS] |
| 14. | Lin CH, Lin CH, Chang CC, Wei TS, Cheng SF, Chen SS, Chang DK* An efficient production and characterization of HIV-1 gp41 ectodomain with fusion peptide in Escherichia coli system. Journal of Biotechnology 153(1-2), 48-55 (2011-04) [JCR] [WOS] |
| 15. | P. Y. Ke, and (S.S. Chen)* Emergence of a host cellular restriction mechanism on propagation of hepatitis C virus The 19th Symposium on Recent Advances in Cellular and Molecular Biology (2011-02) [JCR] [WOS] |
| 16. | Ke PY, Chen SS* Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro. The Journal of Clinical Investigation 121(1), 37-56 (2011-01) [JCR] [WOS] |
| 17. | P.Y. Ke, and (S.S. Chen)* Autophagic control of hepatitis C virus RNA replication through repression of the innate immune response 17th International Meeting on Hepatitis C Virus and Related Virus (2010-09) [JCR] [WOS] |
| 18. | P.Y. Ke, and (S.S. Chen)* Autophagic control of hepatitis C virus RNA replication through repression of the innate immune response Eighteenth Symposium on Recent Advances in Cellular and Molecular biology (2010-01) [JCR] [WOS] |
| 19. | L.S.,Ai, Y.W. Lee, and (S.S. Chen)* Characterization of hepatitis C virus core protein multimerization and membrane envelopment: revelation of a cascade of core-membrane interactions Eighteenth Symposium on Recent Advances in Cellular and Molecular biology (2010-01) [JCR] [WOS] |
| 20. | Yang P, Ai LS, Huang SC, Li HF, Chan WE, Chang CW, Ko CY, Chen SS* The cytoplasmic domain of human immunodeficiency virus type 1 transmembrane protein gp41 ghrbors lipid raft-association determinants Journal of Virology 84(1), 59-75 (2010-01) [JCR] [WOS] |
| 21. | Ai LS, Lee YW, Chen SS* Characterization of hepatitis C virus core protein multimerization and membrane envelopment: revelation of a cascade of core-membrane interactions Journal of Virology 83(19), 9923-9939 (2009-10) [JCR] [WOS] |
| 22. | (S. S. Chen)*, L. S. Ai, and , and Y. W. Lee Characterization of membrane envelopment of hepatitis C virus core protein: a critical step for virus assembly/budding 16th International Symposium on Hepatitis C and Related Viruses (2009-10) [JCR] [WOS] |
| 23. | Li HF, Huang CH, Ai LS, Chuang CK, Chen SS* Mutagenesis of the fusion peptide-like domain of hepatitis C virus E1 glycoprotein: involvement in cell fusion and virus entry Journal of Biomedical Science 16, 89 (2009-09) [JCR] [WOS] |
| 24. | L.S. Ai, C.K. Chuang, and (S.S. Chen)* Assessment of hepatitis C virus core protein function by a trans-packaging system Seventeenth Symposium on Recent Advances in Cellular and Molecular biology (2009-02) [JCR] [WOS] |
| 25. | P.Y. Ke, C Shih, and (S.S. Chen)* Stable growth of hepatitis C virus in cell culture: a novel model for study of host-virus interactions Seventeenth Symposium on Recent Advances in Cellular and Molecular biology (2009-02) [JCR] [WOS] |
| 26. | Chen SS*, Yang P, Ke PY, Li HF, Chan WE, Chang DK, Chuang CK, Tsai Y, and Huang SC Identification of the LWYIK motif located in the human immunodeficiency virus type 1 transmembrane gp41 protein as a distinct determinant for viral infection Journal of Virology 83(2), 870-883 (2009-01) [JCR] [WOS] |
| 27. | Hsiao-Fen Li, Chia-Hsuan Huang, and Steve S.-L Involvement of the Putative Fusion Domain Located in Hepatitis C Virus E1 Glycoprotein in Virus Infection 15th International Symposium on Hepatitis C Virus and Related Viruses (2008-10) [JCR] [WOS] |
| 28. | Ke, P.Y. and Chen, S.S. Proteomic and functional analysis of hepatitis C virus NS5A protein The 8th Symposium on Graduate Institute of Life Science, National Defense Medical Center. (2008-06) [JCR] [WOS] |
| 29. | Chen, S. and P. Yang Identification and characterization of determinants of HIV-1 gp41 cytoplasmic domain crucial for Env association with lipid rafts Keystone Symposium on Cell Biology of Virus Entry, Replication, and Pathogenesis (2008-04) [JCR] [WOS] |
| 30. | Chen, S. S. dentification and characterization of determinants in HIV-1 gp41 cytoplasmic tail crucial for Env targeting to lipid rafts 1st UK-Taiwan International Networking for Young Scientists Symposium on Infection and Immunity (2008-03) [JCR] [WOS] |
| 31. | Li, H.F., Huang, C.H., and Chen, S.S. Functional Characterization of the putative fusion domain located in hepatitis C virus envelope glycoprotein 1 in cell fusion and virus entry The 23rd Joint Annual Conference of Biomedical Sciences (2008-03) [JCR] [WOS] |
| 32. | Yang, P., and Chen, S.S. Identification and characterization of determinants in HIV-1 gp41 cytoplasmic tail crucial for Env targeting to lipid rafts. The 23th Joint Annual Conference of Biomedical Science (2008-03) [JCR] [WOS] |
| 33. | Ai, L.S., Li, H.F., Lee, Y.W., and Chen, S.S. The Sequential and Concerted Process During the Association of the Hepatitis C Virus Core Protein with Membranes The 23th Joint Annual Conference of Biomedical Science (2008-03) [JCR] [WOS] |
| 34. | Chan WE, Chen SS* The dominant-negative action of a fusion protein containing the cytoplasmic domain of human immunodeficiency virus type 1 transmembrane protein gp41 in virus replication Journal of Biomedical Science 14(6), 717-729 (2007-11) [JCR] [WOS] |
| 35. | Ai, L.-S., Li, H.-F., Chen, S. S.-L The Sequential and Concerted Process during the Association of Hepatitis C Virus Core Protein with Intracellular Membranes. International Symposium on Hepatitis C Virus & Related Viruse (2007-09) [JCR] [WOS] |
| 36. | Chiou SH, Yang YP, Lin JC, Hsu CH, Jhang HC, Yang YT, Lee CH, Ho LL, Hsu WM, Ku HH, Chen SJ, Chen SS, Chang MD, Wu CW* Juan LJ* The immediate early 2 protein of human cytomegalovirus (HCMV) mediates the apoptotic control in HCMV retinitis through up-regulation of the cellular FLICE-inhibitory protein expression Journal of Immunology 177, 6199-6206 (2006-11) [JCR] [WOS] |
| 37. | Chen, S., S.-L The LWYIK motif located in the HIV-1 transmembrane protein gp41 is a distinct membrane fusion determinant The third Taiwan-Japan Symposium on HIV/AIDS Oral Presentation (2006-09) [JCR] [WOS] |
| 38. | Chen, S. S.-L. and Chan, W.- ERole of the highly conserved LWYIK motif of the HIV-1 transmembrane protein gp41 in Env-mediated membrane fusion XVI International AIDS Conference Oral Presentation (2006-08) [JCR] [WOS] |
| 39. | Chan WE, Chen SS* Downregulation of human immunodeficiency virus type 1 Gag expression by a gp41 cytoplasmic domain fusion protein Virology 348(2), 418-429 (2006-05) [JCR] [WOS] |
| 40. | Chan WE, Chuang CK, Yeh SH, Chang MS, Chen SS* Functional characterization of heptad repeat 1 and 2 mutants of the spike protein of severe acute respiratory syndrome coronavirus Journal of Virology 80(7), 3225-3237 (2006-04) [JCR] [WOS] |
| 41. | Chan WE, Lin HH, Chen SS* Wild-type-like viral replication potential of human immunodeficiency virus type 1 envelope mutants lacking palmitoylation signals Journal of Virology 79(13), 8374-8387 (2005-07) [JCR] [WOS] |
| 42. | Peng CH, Chen SJ, Ho CK, Ku HH, Lin H-W, Chen SS, Wu CC, Chi CW, Hsu WM, Chiou SH* Detection of HIV RNA levels in intraocular and cerebrospinal fluids in patients with AIDS-related cryptococcosis Ophthalmologica 219(2), 101-106 (2005-03) [JCR] [WOS] |
| 43. | Ai LS, Lee SF, Chen SS, Liao F* Molecular characterization of CCR6: involvement of multiple domains in ligand binding and receptor signaling Journal of Biomedical Science 11(6), 818-828 (2004-11) [JCR] [WOS] |
| 44. | Hsu WM*, Chiou SH, Chen SS., Shyong MP, Ho CK, Chen SJ, Wu CC, Kung SH, Chi CW. The HIV RNA levels of plasma and ocular fluids in AIDS patients with ophthalmic infections Ophthalmologica 218(5), 328-332 (2004-09) [JCR] [WOS] |
| 45. | Chan, W.-E., Wang, Y.-L., Lin, H.-H., and Chen, S. S.-L. Effect of HIV-1 Env cytoplasmic tail elongation on virus replication XV International AIDS Conference (2004-07) [JCR] [WOS] |
| 46. | Chan WE, Wang YL, Lin HH, Chen SS* Effect of extension of the cytoplasmic domain of human immunodeficiency type 1 virus transmembrane protein gp41 on virus replication Journal of Virology 78(10), 5157-5169 (2004-05) [JCR] [WOS] |
| 47. | Chen SW, Chiu HC, Liao WH, Wang FD, Chen SS, Wang CT* The virus-associated human immunodeficiency virus type 1 Gag-Pol carrying an active protease domain in the matrix region is severely defective both in autoprocessing and in trans processing of gag particles Virology 318(2), 534-541 (2004-01) [JCR] [WOS] |
| 48. | Chen, S. S.-L., and Chan, W.-E A cytoplasmic domain fusion protein of the transmembrane glycoprotein gp41 confers dominant interference with human immunodeficiency type 1 virus infectivity 2nd IAS Conference on HIV Pathogenesis and Treatment (2003-07) [JCR] [WOS] |
| 49. | Hsu WM*, Chen SS, Peng CH, Chen CF, Ko YC, Tsai DC, Chou CK, Ho LL, Chiou SH, and Liu JH Elevated nitric oxide level in aqueous humor of AIDS patients with cytomegalovirus retinitis Ophthalmologica 217(4), 298-301 (2003-07) [JCR] [WOS] |
| 50. | Chen, S. S.-L. Lee, S.-F., Wang, C.-T., and Ko, C.-Y Determinants in the lentivirus lytic peptide-1 sequence of human immunodeficiency virus type 1 transmembrane protein gp41 important for envelope stability XIV International AIDS Conference (2002-07) [JCR] [WOS] |
| 51. | Lee SF, Ko CY, Wang CT, Chen SS* Effect of point mutations in the N terminus of the lentivirus lytic peptide-1 sequence of human immunodeficiency virus type 1 transmembrane protein gp41 on Env stability Journal of Biological Chemistry 277(18), 15363-15375 (2002-05) [JCR] [WOS] |
| 52. | Chiou SH, Liu JH, Chen SS, Liu WT, Lin JC, Wong WW, Tseng WS, Chou CK, Liu CY, Ho LL, Hsu WM* Apoptosis of human retina and retinal pigment cells induced by human cytomegalovirus infection Ophthalmic Research 34(2), 77-82 (2002-03) [JCR] [WOS] |
| 53. | Chen SS*, Lee SF, Wang CT Cellular membrane-binding ability of the C-terminal cytoplasmic domain of human immunodeficiency virus type 1 envelope transmembrane protein gp41 Journal of Virology 75(20), 9925-9938 (2001-10) [JCR] [WOS] |
| 54. | Chiou SH, Liu JH, Hsu WM, Chen SS, Chang SY, Juan LJ, Lin JC, Yang YT, Wong WW, Liu CY, Lin YS, Liu WT, Wu CW* Up-regulation of Fas ligand expression by human cytomegalovirus immediate-early gene product 2: a novel mechanism in cytomegalovirus-induced apoptosis in human retina Journal of Immunology 167(7), 4098-4103 (2001-10) [JCR] [WOS] |
| 55. | Chen, S. S.-L., Lee, S.-F., and C.-T. Wang Interactions of the C-terminal cytoplasmic domain of the HIV-1 envelope transmembrane protein gp41 with intracellular membranes in cells The 9th SCBA International Symposium (2001-08) [JCR] [WOS] |
| 56. | Wang CT*, Chen SS, Chiang CC Assembly and release of human immunodeficiency virus type 1 Gag proteins containing tandem repeats of the matrix protein coding sequences in the matrix domain Virology 278(1), 289-298 (2000-12) [JCR] [WOS] |
| 57. | Chen, S. S.-L., Liang, Y. P., Lee, S.-F., and Hang, C.-C. Multimeric structure of the cytoplasmic domain of the human immunodeficiency virus type 1 transmembrane glycoprotein American Society for Microbiology-100th General Meeting (2000-05) [JCR] [WOS] |
| 58. | Lee SF, Wang CT, Liang JY, Hong SL, Huang CC, Chen SS* Multimerization potential of the cytoplasmic domain of the human immunodeficiency virus type 1 transmembrane glycoprotein gp41 Journal of Biological Chemistry 275(21), 15809-15819 (2000-05) [JCR] [WOS] |
| 59. | Wang, C.-T., Chen, S.-L., and Chiang, C. C Analysis of HIV-1 gag mutant with tandem repeats of the matrix central coding sequences. 13th International AIDS Conference (2000) [JCR] [WOS] |
| 60. | Chen SS*, Lee SF, Chuang CK, Raj VS trans-dominant interference with human immunodeficiency virus type 1 replication and transmission in CD4(+) cells by an envelope double mutant Journal of Virology 73(10), 8290-8302 (1999-10) [JCR] [WOS] |
| 61. | Chuang CK, Lee SF, Chen SS* Conferral of an antiviral state to CD4+ cells by a zipper motif envelope mutant of the human immunodeficiency virus type 1 transmembrane protein gp41 Human Gene Therapy 10, 2381-2395 (1999-09) [JCR] [WOS] |
| 62. | Chen, S. S.-L., Lee, S.-F., Hao, H.-Y., and Chuang, C.-K. Mutations in the leucine zipper-like heptad repeat sequence of HIV-1 gp41 dominantly interfere with wild-type virus infectivity 12th World AIDS Conference (1998-06) [JCR] [WOS] |
| 63. | Chen SS*, Lee SF, Hao HJ, Chuang CK Mutations in the leucine zipper-like heptad repeat sequence of human immunodeficiency virus type 1 gp41 dominantly interfere with wild-type virus infectivity Journal of Virology 72(6), 4765-4774 (1998-06) [JCR] [WOS] |
| 64. | Chen SS, Ferrante AA, Terwilliger EF* Characterization of an envelope mutant of HIV-1 that interferes with viral infectivity Virology 226(2), 260-268 (1996-12) [JCR] [WOS] |
| 65. | Jiang MC, Lin JK, Chen SS* Inhibition of HIV-1 Tat-mediated transactivation by quinacrine and chloroquine Biochemical and Biophysical Research Communications 226(1), 1-7 (1996-09) [JCR] [WOS] |
| 66. | Chen, S. S.-L., and Terwilliger, E. . Interference with the infectivity of HIV-1 by an envelope mutant XI International Congress on AIDS (1996-07) [JCR] [WOS] |
| 67. | Chen SS* Expression and processing of the human immunodeficiency virus type 1 envelope glycoprotein Intervirology 39, 242-248 (1996) [JCR] [WOS] |
| 68. | Chen, S.S., and Terwilliger, E. Interference with the infectivity of HIV-1 by an envelope mutant XI International Congress on AIDS (1995-07) [JCR] [WOS] |
| 69. | Chen SS* Functional role of the zipper motif region of human immunodeficiency virus type 1 transmembrane protein gp41 Journal of Virology 68(3), 2002-2010 (1994-03) [JCR] [WOS] |
| 70. | Chen SS*, Lee CN, Lee WR, McIntosh K, Lee TH Mutational analysis of the leucine zipper-like motif of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein Journal of Virology 67(6), 3615-3619 (1993-06) [JCR] [WOS] |
| 71. | Chen SS* Myristylation of the envelope glycoprotein of vesicular stomatitis virus Intervirology 32, 193-197 (1991) [JCR] [WOS] |
| 72. | Zhu ZH, Chen SS, Huang AS* Phenotypic mixing between human immunodeficiency virus and vesicular stomatitis virus or herpes simplex virus Journal of Acquired Immune Deficiency Syndromes 3(3), 215-219 (1990) [JCR] [WOS] |
| 73. | Chen SS*, Huang AS Human cervical carcinoma cell lines contain an antigen identical to the tumor-specific 75 kDa antigen of HeLa cells: detection by viral acquisition Journal of Virological Methods 24, 159-167 (1989-04) [JCR] [WOS] |
| 74. | Fan W, Chen SS, Huang AS* Multiple thermolabile and temperature-sensitive lesions in mutant tl17 of vesicular stomatitis virus Intervirology 30, 148-155 (1989) [JCR] [WOS] |
| 75. | Chen SS*, Ariel N, Huang AS Membrane anchors of vesicular stomatitis virus: characterization and incorporation into virions Journal of Virology 62(8), 2552-2556 (1988-08) [JCR] [WOS] |
| 76. | Huang, AS.*, Chen SS Membrane anchors of vesicular stomatitis virus Virus Research Supplement 2, pp. 6 (1988) [JCR] [WOS] |
| 77. | Chen SS*,.Doherty R, O\'Rourke EJ, Ariel N, Huang AS Effects of transport inhibitors on the generation and transport of a soluble viral glycoprotein Virology 160, 482-484 (1987-10) [JCR] [WOS] |
| 78. | Chen SS, Huang AS* Further characterization of the vesicular stomatitis virus temperature-sensitive O45 mutant: intracellular conversion of the glycoprotein to a soluble form Journal of Virology 59(2), 210-215 (1986-08) [JCR] [WOS] |
| 79. | Reiss CS*, Chen SS, Huang AS, Doherty R VSV G protein induces murine cytolytic T lymphocytes Microbial Pathogenesis 1(3), 261-267 (1986-06) [JCR] [WOS] |
| 80. | Chen SL, Kim KH* Effect of sulfhydryl-disulfide state on protein phosphorylation: phosphorylation of bovine serum albumin Archives of Biochemistry and Biophysics 239(1), 163-171 (1985) [JCR] [WOS] |
| 81. | Chen SL, Kim KH* Identification of the cyclic AMP and ATP binding sites of acetyl coenzyme A carboxylase by use of 5\'-p-fluorosulfonylbenzoyladenosine The Journal of Biological Chemistry 257(17), 9953-9957 (1982) [JCR] [WOS] |
| 82. | Chen SL, Song HY, Su JC* Purification and general properties of uridine diphosphate D-glucose pyrophosphorylase from tobacco leaves J. Chinese Biochem. Soc. 10, 1-18. (1981) [JCR] [WOS] |