Dr. Tai, Jung-Hsiang 戴榮湘 博士
Ph.D. Michigan State University
Our research focuses on signal transduction and transcription regulation of the human pathogen, Trichomonas vaginalis. We have previously developed a model to study molecular mechanism underlying iron-regulated transcription regulation and identified that some of the promoter elements were the target sites of multiple Myb transcription factors, among which the Myb2 and Myb3 transcription activators and Myb1 transcription repressor were shown to act in concert at multiple cellular levels in controlling iron-inducible transcription of an adhesion protein,ap65-1, gene. Recent progresses have shed light on the cellular mechanisms underlying: 1.), the regulation of nuclear translocation of Myb1, Myb2 and Myb3; 2), the regulation of Myb3 stability; and 3), the signal transduction triggered by iron. Our future research will focus on signal transduction and gene expression triggered by iron and hydrogen peroxide to study how the parasite copes with challenges from host environments.
本室研究著重於人類陰道滴蟲的轉錄調控與訊息傳遞。我們以建立的好的模式研究受鐵調節轉錄的分子機制；利用這個系統模式，已找到和不同Myb轉錄因子作用的起動子位置。Myb轉錄因子包括活化轉錄的Myb2和Myb3，以及抑制轉錄的Myb1；它們顯然在不同細胞層面協力調控受鐵誘導基因ap65-1的轉錄。近來利用分子生物學，細胞生物學，和蛋白質體學的方法，下列各項的細胞機制已漸漸明白： 1) Myb1, Myb2和Myb3進入細胞核的調節；2) Myb3穩定性的調節；3)鐵引發的訊息傳遞。未來的研究重點在探討鐵和過氧化氫所引發的訊息傳遞與基因表現，瞭解陰道滴蟲在宿主環境中面對的挑戰。
