Dr. Tai, Jung-Hsiang 's publons link picture

Dr. Tai, Jung-Hsiang

Adjunct Research Fellow
Specialty:
  • Molecular Biology
Education and Positions:

  • Ph.D. Michigan State University

Our research focuses on signal transduction and transcription regulation of the human pathogen, Trichomonas vaginalis. We have previously developed a model to study molecular mechanism underlying iron-regulated transcription regulation and identified that some of the promoter elements were the target sites of multiple Myb transcription factors, among which the Myb2 and Myb3 transcription activators and Myb1 transcription repressor were shown to act in concert at multiple cellular levels in controlling iron-inducible transcription of an adhesion protein,ap65-1, gene. Recent progresses have shed light on the cellular mechanisms underlying: 1.), the regulation of nuclear translocation of Myb1, Myb2 and Myb3; 2), the regulation of Myb3 stability; and 3), the signal transduction triggered by iron. Our future research will focus on signal transduction and gene expression triggered by iron and hydrogen peroxide to study how the parasite copes with challenges from host environments.
Our Team
Team photo

Journal 31 Book 0

  1. Hong-Ming Hsu, Yu-Hsin Huang, Sarita Aryal, Hsing-Wei Liu, Chinpan Chen, Shu-Hui Chen, Chien-Hsin Chu* & Jung-Hsiang Tai* Endomembrane protein trafficking regulated by a TvCyP2 cyclophilin in the protozoan parasite, Trichomonas vaginalis. SCIENTIFIC REPORTS 10(1),1275 (2020-01) [JCR] [WOS]
  2. Martin, T., Lou, Y. C., Chou, C.C., Wei, SY, Sadotra, S. Cho, CC, Lin, MH, Tai, J. H., Hsu, CH, and Chen C. Structural basis of interaction between dimeric cyclophilin 1 and Myb1 transcription factor in Trichomonas vaginalis SCIENTIFIC REPORTS 8, 5410 (2018-04) [JCR] [WOS]
  3. Chu CH, Huang YH, Liu HW, Hsu HM, Tai JH Membrane localization of a Myb3 transcription factor regulated by a TvCyP1 cyclophilin in the parasitic protozoan Trichomonas vaginalis The FEBS Journal 285(5), 929-946 (2018-01-11) [JCR] [WOS]
  4. Ku, M. C., Fang, C. M., Cheng, J. T., Liang, H. C., Wang, T. F., Wu, C. H., Chen, C. C., Tai, J. H., Chen, S. H. Site-specific covalent modifications of human insulin by catechol estrogens: Reactivity and induced structural and functional changes SCIENTIFIC REPORTS 6:28804 (2016-06) [JCR] [WOS]
  5. Arroyo R, Ochoa T, Tai JH, de la Garza M Iron and Parasites. Biomed Research International 2015, 291672 (2015) [JCR] [WOS]
  6. Hsu, H. M., Lee, Y., Liu, H. W., Chu, C. H., Chen, Y. R., Chen, S. H., Hsu, P. H., and J. H. Tai Signal transduction triggered by iron to induce the nuclear translocation of a Myb3 transcription factor in the protozoan parasite, Trichomonas vaginalis. Journal of Biological Chemistry 289, 29334-29349 (2014-11) [JCR] [WOS]
  7. Hsu, H. M., Chu, C. H., Wang, Y. T., Lee, Y., Wei, S. Y., Liu, H. W., Ong, S. J., Chen, C., and J. H. Tai*. Regulation of nuclear translocation of the Myb1 transcription factor by TvCyclophilin 1 in the protozoan parasite, Trichomonas vaginalis. JOURNAL OF BIOLOGICAL CHEMISTRY 289(27), 19120-19136 (2014-07) [JCR] [WOS]
  8. Wei SY, YC Lou, JY Tsai, MR Ho, M Rajasekaran, HM Hsu, (JH Tai), YC Liaw, and TH Huang Structure of the Trichomonas vaginalis Myb3 DNA-binding domain bound to a promoter sequence reveals a unique C-terminal b-hairpin conformation. NUCLEIC ACIDS RESEARCH 40(1), 449-460 (2012-01) [JCR] [WOS]
  9. Hsu, H. M., Lee, Y., Indra, D., Wei, S. Y., Liu, H. S., Chang, L. C., Chen, C., Ong, S. J. and J.H. Tai.* Iron-inducible nuclear translocation of a Myb3 transcription factor in the protozoan parasite Trichomonas vaginalis. EUKARYOTIC CELL 11(12), 1441-1450 (2012) [JCR] [WOS]
  10. Chu CH, LC Chang, HM Hsu, SY Wei, HW Liu, Y Lee, CC Kuo, C Chen, SJ Ong and (JH Tai)* A highly organized structure mediating nuclear localization of a Myb2 transcription factor in the protozoan parasite Trichomonas vaginalis. EUKARYOTIC CELL 10, 1607-1617 (2011-10) [JCR] [WOS]
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