Dr. Chen, Chien-Chang 's orcid link picture Dr. Chen, Chien-Chang 's publons link picture

Dr. Chen, Chien-Chang

Research Fellow
  • 02-2652-3944 (Lab) (Room No: N713)
  • 02-2652-3522 (Office)

Specialty:
  • Chronic Pain
  • Calcium Channel
  • Cardiovascular Disease

Education and Positions:
  • Ph.D., University of Illinois, Urbana-Champaign


Our laboratory focuses on the mechanisms underlying the development of persistent chronic pain using optogenetics, chemogenetics, in vivo imaging, gene targeting, electrophysiological, pharmacological and behavioral approaches in wild type and genetically modified mice.
 
Our research interests include:
 
1. To delineate the role of anterior nucleus of paraventricular thalamus (PVA) in chronic pain.  Our studies show that PVA is involved in the development and maintenance of chronic in several rodent models. We are examining the circuits through which PVA involves in chronic pain.
 
2. To understand the formation of hyperalgesia priming. Chronic pain can be initiated by one or more acute tissue insults to sensitize the neurons into the primed state; however, the mechanism underlying the priming effect is unclear. We are investigating the role of neurons and non-neuronal cells in hyperalgesia priming using acid-induced muscle pain (AIMP) model.
 
3. To investigate whether aging accelerates the development or duration of chronic pain.
Our Team
Team photo

Journal 56 Book 0

  1. Yeh Hsiao-hui, Chang Yao-Ming, Chang Yu-Wang, Lu Mei-Yeh Jade, Chen Yi-Hua, Lee Chia-Che, Chen Chien-Chang Multiomic analyses reveal enriched glycolytic processes in β-myosin heavy chain-expressed cardiomyocytes in early cardiac hypertrophy Journal of Molecular and Cellular Cardiology Plus 1, 100011 (2022-09) [JCR] [WOS]
  2. Herzig, V.*†, Chen, Y.C.,†, Chin, Y.K.Y., Dekan, Z., Chang, Y-W, Yu, H.M., Alewood, P.F., (Chen, C.C),* and King, G.F.* The Tarantula Toxin ω-Avsp1a Specifically Inhibits Human CaV3.1 and CaV3.3 via the Extracellular S3-S4 Loop of the Domain 1 Voltage-Sensor biomedicines 10(5), 1066 (2022-05-04) [JCR] [WOS]
  3. Tamang, H.K., Yang, R.B., Song, Z.H., Hsu, S.C., Peng, C.C, Tung, Y.C, Tzeng, B.H.*, and (Chen, C.C.)* Cav3.2 T‐type calcium channel regulates mouse platelet activation and arterial thrombosis Journal of Thrombosis and Haemostasis (2022-05-01) [JCR] [WOS]
  4. Chen, W.H., Lien, C.C., (Chen, C.C.)* Neuronal basis for pain- and anxiety-like behaviors in the central nucleus of the amygdala PAIN 163(3), e463-e475 (2022-03-01) [JCR] [WOS]
  5. Hu, Y.F., Lee, A.S., Chang, S.L., Lin, S.F., Weng, C.H., Lo, H.Y., Chou, P.C., Tsai, Y.N., Sung, Y.L., (Chen, C.C.), Yang, R.B., Lin, Y.C. Kuo, T.B., Wu, C.H., Liu, J.D., Chung, T.W., & Chen, S.A. Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats. Nature Biomedical Engineering (2021-11-22) [JCR] [WOS]
  6. Chang, Y.W., Song, Z.H. & (Chen, C.C.)* FAK regulates cardiomyocyte mitochondrial fission and function through Drp1. FEBS JOURNAL (2021-11-05) [JCR] [WOS]
  7. Brandon-Mong, GJ; Shaw, GTW; Chen, WH; (Chen, CC); Wang, DR A network approach to investigating the key microbes and stability of gut microbial communities in a mouse neuropathic pain model BMC MICROBIOLOGY 20(1), 295 (2020-09-30) [JCR] [WOS]
  8. Chang, C.S., Liao, C.C., Liou, A.T., Chang, Y.S., Chang, Y.T., Tzeng, B.H., (Chen, C.C.), & Shih, C. Enterovirus 71 targets the cardiopulmonary system in a robust oral infection mouse model. SCIENTIFIC REPORTS 9(1):11108 (2019-07-31) [JCR] [WOS]
  9. Chang, Y.T., Chen, W.H., Shih, H.C., Shyu, B.C., Min, M.Y. & (Chen, C.C.) Anterior nucleus of paraventricular thalamus mediates chronic mechanical hyperalgesia PAIN 160(5), 1208-1223 (2019-05) [JCR] [WOS]
  10. Huang, I.Y., Hsu, Y.L., (Chen, C.C.), Chen, M.F., Wen, Z.H., Huang, H.T. &Liu, I.Y. Excavatolide-B enhances contextual memory retrieval via repressing the delayed rectifier potassium current in the hippocampus MARINE DRUGS 16(11), 405 (2018-10-25) [JCR] [WOS]

- POSTDOC -
Chang, Yu-Wang
Chang, Yu-Wang
Chen, Wei-Hsin
Chen, Wei-Hsin
- RESEARCH ASSOCIATES -
Chen, Yong-Cyuan
Chen, Yong-Cyuan
Song, Zong-Han
Song, Zong-Han
- STUDENTS -
Abdel Aziz, Mohamed Abbas Abdel Hafez
Abdel Aziz, Mohamed Abbas Abdel Hafez
Mindaye, Selomon Assefa
Mindaye, Selomon Assefa
Liang, Shao-Feng
Liang, Shao-Feng
- ALUMNI -
Cheng, Yi-Fen
Cheng, Yi-Fen
Chang, Ya-Ting
Chang, Ya-Ting
Yeh, Hsiao-Hui
Yeh, Hsiao-Hui
TAMANG, HEM KUMAR
TAMANG, HEM KUMAR