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Dr. Fann, Cathy S.-J.

Research Fellow
  • 02-27899144 (Lab) (Room No: 100)
  • 02-27823047 (Fax)

Specialty:
  • Genetic Statistics
  • Genetic Epidemiology

Education and Positions:
  • Division of Biostatistics, Department of Preventive Medicine and Environmental Health,
    Ph.D. University of Iowa, Iowa City, Iowa, US


The major research interest of our laboratory is using biostatistical methods and bioinformatic tools in disease gene mapping, comparative genomics, population genetics, and phylogenetic analysis. We develop novel statistical methods/software and apply frequently used analytical tools to locate chromosomal positions of disease susceptibility genes.


The ongoing projects are shown below:

1. Applying statistical methods and tools to identify genes that are associated with human complex diseases such as Migraine, Dementia, Bipolar disorder, Asthma,  Metabolic syndrome  etc.

2. Developing new statistical methods for rare variants detection and their possible impact to specific population.

3. Developing machine learning or deep learning (ML/DL) based methods to facilitate disease gene mapping for the polygenic architecture of complex diseases.

4. Developing methods for analyzing large biobank data and comparing susceptible disease genes among different populations.

Our Team
Team photo

Journal 145 Book 2

  1. Cheng YW, Liao YC, Chen CH, Chung CP, Fann CSJ, Chang CC, Lee YC, Tang SC. Contribution of the APOE Genotype to Cognitive Impairment in Individuals With NOTCH3 Cysteine-Altering Variants. Journal of the American Heart Association e032689, e032689 (2023-11) [JCR] [WOS]
  2. Lee CT, Tsai WH, Chang CC, Chen PC, Fann CS, Chang HK, Liu SY, Wu MZ, Chiu PC, Hsu WM, Yang WS, Lai LP, Tsai WY, Yang SB, Chen PL. Genotype-phenotype correlation in Taiwanese children with diazoxide-unresponsive congenital hyperinsulinism. Frontiers in Endocrinology 14:1283907., 14:1283907. (2023-11) [JCR] [WOS]
  3. Winsvold BS, Harder AVE, Ran C, Chalmer MA, Dalmasso MC, Ferkingstad E, Tripathi KP, Bacchelli E, Børte S, Fourier C, Petersen AS, Vijfhuizen LS, Magnusson SH, O\'Connor E, Bjornsdottir G, Häppölä P, Wang YF, Callesen I, Kelderman T, Gallardo VJ, de Boer I, Olofsgård FJ, Heinze K, Lund N, Thomas LF, Hsu CL, Pirinen M, Hautakangas H, Ribasés M, Guerzoni S, Sivakumar P, Yip J, Heinze A, Küçükali F, Ostrowski SR, Pedersen OB, Kristoffersen ES, Martinsen AE, Artigas MS, Lagrata S, Cainazzo MM, Adebimpe J, Quinn O, Göbel C, Cirkel A, Volk AE, Heilmann-Heimbach S, Skogholt AH, Gabrielsen ME, Wilbrink LA, Danno D, Mehta D, Guðbjartsson DF; HUNT All-In Headache, The International Headache Genetics Consortium, DBDS Genomic Consortium; Rosendaal FR, Willems van Dijk K, Fronczek R, Wagner M, Scherer M, Göbel H, Sleegers K, Sveinsson OA, Pani L, Zoli M, Ramos-Quiroga JA, Dardiotis E, Steinberg A, Riedel-Heller S, Sjöstrand C, Thorgeirsson TE, Stefansson H, Southgate L, Trembath RC, Vandrovcova J, Noordam R, Paemeleire K, Stefansson K, Fann CS, Waldenlind E, Tronvik E, Jensen RH, Chen SP, Houlden H, Terwindt GM, Kubisch C, Maestrini E, Vikelis M, Pozo-Rosich P, Belin AC, Manjit Matharu, Arn M J M van den Maagdenberg, Thomas F Hansen, Alfredo Ramirez, John-Anker Zwart; International Consortium for Cluster Headache Genetics. Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor. Annals of Neurology 2023-07, 07-24 (2023-07) [JCR] [WOS]
  4. Chen TH, Hsu HC, You JF, Lai CC, Tsou YK, Hsu CL, Fann CSJ, Chien RN, Chang ML. Extracellular Nicotinamide Phosphoribosyltransferase as a Surrogate Marker of Prominent Malignant Potential in Colonic Polyps: A 2-Year Prospective Study. Cancers. 15(6):1702., 1702-1702 (2023-03) [JCR] [WOS]
  5. Lian IB, Sie JJ, Chang CC, Fann CSJ, Huang CH. Effects of insomnia and non-vasomotor menopausal symptoms on coronary heart disease risk: a mendelian randomization study. Heliyon. 9(2):e13569, e13569-e13569 (2023-02) [JCR] [WOS]
  6. Chen SP, Hsu CL, Wang YF, Yang FC, Chen TH, Huang JH, Pan LH, Fuh JL, Chang HC, Lee YL, Chang HC, Lee KH, Chang YC, Fann CS*, Wang SJ. Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan. J Headache Pain. 23(1), 147 (2022-11-21) [JCR] [WOS]
  7. Lee CJ, Chen TH, Lim AMW, Chang CC, Sie JJ, Chen PL, Chang SW, Wu SJ, Hsu CL, Hsieh AR, Yang WS, Fann CSJ* Phenome-wide analysis of Taiwan Biobank reveals novel glycemia-related loci and genetic risks for diabetes Commun Biol. 5(1), 1175 (2022-11-03) [JCR] [WOS]
  8. Geevimaan K, Guo JY, Shen CN, Jiang JK, Fann CSJ, Hwang MJ, Shui JW, Lin HT, Wang MJ, Shih HC, Li AF, Chang SC, Yang SH, Chen JY. Patient-Derived Organoid Serves as a Platform for Personalized Chemotherapy in Advanced Colorectal Cancer Patients. Front Oncol. 12, 883437 (2022-06-01) [JCR] [WOS]
  9. Jiang YJ, Fann CS, Fuh JL, Chung MY, Huang HY, Chu KC, Wang YF, Hsu CL, Kao LS, Chen SP, Wang SJ. Genome-wide analysis identified novel susceptible genes of restless legs syndrome in migraineurs. J Headache Pain 23(1), 39-39 (2022-03) [JCR] [WOS]
  10. Tsao YC, Wang SJ, Hsu CL, Wang YF, Fuh JL, Chen SP, Fann CS. Genome-wide association study reveals susceptibility loci for self-reported headache in a large community-based Asian population. Cephalalgia. 42(3), 229-238 (2022-03) [JCR] [WOS]

- POSTDOC -
LO, YEN-LI
LO, YEN-LI
- RESEARCH ASSOCIATES -
Chang, Chien-Ching
Chang, Chien-Ching
Hsu	, Chia-Lin
Hsu , Chia-Lin
Wu, Shang-Jung
Wu, Shang-Jung
Lim, Evan Unit
Lim, Evan Unit
CHEN, SYUE PU
CHEN, SYUE PU
- STUDENTS -
SIE, JIA-JYUN
SIE, JIA-JYUN
LIM, Aylwin Ming Wee
LIM, Aylwin Ming Wee
- VISITOR -
Chen, Ting-Huei
Chen, Ting-Huei
- ALUMNI -
Lee, CJ
Lee, CJ
tom, thomas
tom, thomas