Dr. Yang, Ruey-Bing (Ray)'s publons link picture

Dr. Yang, Ruey-Bing (Ray)

Acting Director
Research Fellow
  • (02) 2789-9063 (Lab) (Room No: N427)
  • (02) 2652-3943
  • (02) 2785-8847 (Fax)
Specialty:

Signal transduction

Receptor biology

Vascular biology

Education and Positions:

  • Ph.D., University of Texas Southwestern Medical Center at Dallas

    Postdoctoral Fellow, Genentech, Inc.

        This laboratory is interested in understanding the basic and translational biology of a secreted and membrane SCUBE (signal peptide-CUB-EGF domain-containing protein) family originally identified from endothelial cells (ECs). Three different members (SCUBE1 to 3) have been identified and appear to be evolutionarily conserved in vertebrates from zebrafish and mice to humans. We showed that SCUBEs are multi-functional proteins depending on their subcellular localization and distribution. For example, plasma SCUBE1 released from activated platelets not only serves as a biomarker for acute coronary syndrome and acute ischemic stroke also actively participates in arterial thrombosis via its adhesive EGF-like repeats in vivo, suggesting that these adhesive motifs of SCUBE1 might serve as potential anti-thrombotic targets. However, when these SCUBEs expressed as peripheral membrane proteins tethered on the cell surface, they can function as co-receptor in promoting signal activity of various growth factors. We demonstrated that EC SCUBE2 acting as a co-receptor for vascular endothelial growth factor receptor 2 (VEGFR2) regulate VEGF-induced tube formation and proliferation of ECs: it fine-tunes VEGFR2-mediated signaling during postnatal angiogenesis induced by ischemia or during pathological angiogenesis under hypoxic conditions. Together, our studies suggest that targeting SCUBE2 on modulating VEGF signaling might provide potential therapeutic treatment for VEGF-mediated proliferative pathological vascular diseases. Most interestingly, we identified that bi-allelic inactivating variants in SCUBE3 have pleiotropic consequences on development and cause a previously unrecognized syndromic disorder. Eighteen affected individuals from nine unrelated families showed a consistent phenotype characterized by reduced growth, skeletal features, distinctive craniofacial appearance, and dental anomalies. In the future, we will continue to explore their in-depth fundamental biology by the use of genetically-modified mouse models as well as elucidate their translational implications through collaboration with physician scientists in the field of cardiovascular medicine.

Journal 87 Book 0

  1. 3.Udesh Dhawan, Wei-Li Wang, Yuh-Charn Lin, Ruey-Bing Yang, Matthew J. Dalby, Manuel Salmeron-Sanchez, Hsiao-Hua Yu Mechanostimulation-induced integrin αvβ6 and Latency Associated Peptide coupling activates TGF-β and regulates cancer metastasis and stemness NANO TODAY 50, 101882 (2023) [JCR] [WOS]
  2. Yang CW, Hsu HY, Lee YZ, Jan JT, Chang SY, Lin YL, Yang RB, Chao TL, Liang JJ, Lin SJ, Liao CC, Chang CS, Sytwu HK, Hung MS, Chen CT, Lee SJ Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin. Biochemical pharmacology 215, 115688 (2023) [JCR] [WOS]
  3. Tsai MT, Yang RB, Ou SM, Tseng WC, Lee KH, Yang CY, Chang FP, Tarng DC Plasma Galectin-9 Is a Useful Biomarker for Predicting Renal Function in Patients Undergoing Native Kidney Biopsy. Archives of pathology & laboratory medicine 147(2), 167-176 (2023) [JCR] [WOS]
  4. Sahoo BK, Lin YC, Tu CF, Lin CC, Liao WJ, Li FA, Li LH, Mou KY, Roffler SR, Wang SP, Yeh CT, Yao CY, Hou HA, Chou WC, Tien HF, Yang RB Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia. Haematologica 108(5), 1284-1299 (2023) [JCR] [WOS]
  5. Lou YC, Tu CF, Chou CC, Yeh HH, Chien CY, Sadotra S, Chen C, Yang RB, Hsu CH Structural insights into the role of N-terminal integrity in PhoSL for core-fucosylated N-glycan recognition. International journal of biological macromolecules 255, 128309 (2023) [JCR] [WOS]
  6. Lin YC, Sahoo BK, Gau SS, Yang RB The biology of SCUBE. Journal of biomedical science 30(1), 33 (2023) [JCR] [WOS]
  7. Hu YF, Lee AS, Chang SL, Lin SF, Weng CH, Lo HY, Chou PC, Tsai YN, Sung YL, Chen CC, Yang RB, Lin YC, Kuo TBJ, Wu CH, Liu JD, Chung TW, Chen SA Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats. Nature biomedical engineering 6(4), 421-434 (2022) [JCR] [WOS]
  8. Tamang HK, Yang RB, Song ZH, Hsu SC, Peng CC, Tung YC, Tzeng BH, Chen CC Ca(v) 3.2 T-type calcium channel regulates mouse platelet activation and arterial thrombosis. Journal of thrombosis and haemostasis : JTH 20(8), 1887-1899 (2022) [JCR] [WOS]
  9. Prajnamitra RP, Cheng YY, Beh CY, Lu CY, Lin JH, Ruan SC, Chen SL, Chen HC, Yang RB, Hsieh PC Depletion of gut microbiota improves the therapeutic efficacy of cancer nanomedicine. Theranostics 12(17), 7390-7403 (2022) [JCR] [WOS]
  10. Chou PC, Liu CM, Weng CH, Yang KC, Cheng ML, Lin YC, Yang RB, Shyu BC, Shyue SK, Liu JD, Chen SP, Hsiao M, Hu YF Fibroblasts Drive Metabolic Reprogramming in Pacemaker Cardiomyocytes. Circulation research 131(1), 6-20 (2022) [JCR] [WOS]
- More Publications-

- POSTDOC -
Tu, Cheng Fen
Tu, Cheng Fen
Lin, Yuh Charn
Lin, Yuh Charn
- RESEARCH ASSOCIATES -
Gau, Shiang-Shin
Gau, Shiang-Shin
Lin, Yi-Wen
Lin, Yi-Wen
member
Chien, Kai-Ting
- STUDENTS -
CHEN, YI TING
CHEN, YI TING
- ALUMNI -
Wu, Meng Ying
Wu, Meng Ying
Hsiao, Ai Lin
Hsiao, Ai Lin
Chang, Ting Yu
Chang, Ting Yu
CHUNG, PEI CHEN
CHUNG, PEI CHEN
Wu, Ting-Yin
Wu, Ting-Yin
Rao, Vaikar Navakanth
Rao, Vaikar Navakanth
Tsao, Ku Chi
Tsao, Ku Chi
Chao, Ying Chi
Chao, Ying Chi
Sahoo, Binay K.
Sahoo, Binay K.
Liao, Wei Ju
Liao, Wei Ju
Yang, Hsin Yu
Yang, Hsin Yu