Dr. Shieh, Sheau-Yann 's publons link picture

Dr. Shieh, Sheau-Yann

Research Fellow
  • 02-26523916 (Lab) (Room No: N347)
  • 02-27829143 (Fax)
Specialty:
  • Cancer Cell Biology
  • Cell Cycle Signaling
Education and Positions:

  • Ph.D. Baylor College of Medicine Post-doc:Columbia University

Genome stability is maintained by intricate networks of cell cycle checkpoint proteins. In response to genotoxic stress, either extrinsic such as ionizing radiation-induced DNA breaks or intrinsic such as oxidative damage, a cascade of signaling events are initiated to arrest the cell cycle, eliminate damaged cells, or to repair the damage. Defects in these responses often lead to accumulation of mutations and development of cancers. Our studies are focused on targets of the checkpoint pathways involving the tumor suppressors and the checkpoint kinases CHK1 and CHK2, of which mutations are associated with human cancers. Our main goals are to decipher the molecular basis of checkpoint control by these proteins, their functional relationship with DNA repair and genome maintenance, and the impacts on tumorigenesis. By using molecular approaches, cell-based and mouse models, we hope to uncover novel tumor suppressors and their modes of action, through which potential therapeutics could be devised to improve cancer treatment.

Our Team
Team photo

Journal 36 Book 2

  1. Chowdhury MAN, Wang SW, Suen CS, Hwang MJ, Hsueh YA, Shieh SY JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability. Cell death & disease 13(7), 619 (2022) [JCR] [WOS]
  2. Yu-Che Cheng, Sheau-Yann Shieh* Determination of CHK1 Cellular Localization by Immunofluorescence Microscopy Cell Cycle Checkpoints. Methods in Molecular Biology Vol. 2267 1-6 (2021-01) [JCR] [WOS]
  3. Cheng YC, Chiang HY, Cheng SJ, Chang HW, Li YJ, (Shieh SY)* Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation CELL DEATH & DISEASE 11(12), 1046 (2020-12) [JCR] [WOS]
  4. Hsu PC, Gopinath RK, Hsueh YA, Shieh SY CHK2-mediated regulation of PARP1 in oxidative DNA damage response. Oncogene 38(8), 1166–1182 (2019-02) [JCR] [WOS]
  5. Cheng YC, Shieh SY Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation. Proceedings of the National Academy of Sciences of the United States of America 115(21), 5546-5551 (2018) [JCR] [WOS]
  6. Chang CH, Kuo CJ, Ito T, Su YY, Jiang ST, Chiu MH, Lin YH, Nist A, Mernberger M, Stiewe T, Ito S, Wakamatsu K, Hsueh YA, Shieh SY, Snir-Alkalay I, Ben-Neriah Y CK1alpha ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation. Proceedings of the National Academy of Sciences of the United States of America 114(38), E8035-E8044 (2017) [JCR] [WOS]
  7. Yu ZC, Huang YF, Shieh SY Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation. Nucleic acids research 44(3), 1133-1150 (2016) [JCR] [WOS]
  8. Cheng YC, Chen PH, Chiang HY, Suen CS, Hwang MJ, Lin TY, Yang HC, Lin WC, Lai PL, Shieh SY Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT. Cell Death & Disease 6, e1584 (2015) [JCR] [WOS]
  9. Yeh CW, Yu ZC, Chen PH, Cheng YC, Shieh SY Phosphorylation at Threonine 288 by Cell Cycle Checkpoint Kinase 2 (CHK2) Controls Human Monopolar Spindle 1 (Mps1) Kinetochore Localization. The Journal of biological chemistry 289(22), 15319-15327 (2014) [JCR] [WOS]
  10. Cheng YC, Lin TY, Shieh SY Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1. Proceedings of the National Academy of Sciences of the United States of America 110(15), 5993-5998 (2013) [JCR] [WOS]
- More Publications-

- POSTDOC -
Yu-Che, Cheng
Yu-Che, Cheng
- RESEARCH ASSOCIATES -
Lee, Michael
Lee, Michael
Shih-Wei, Wang
Shih-Wei, Wang
- STUDENTS -
Chowdhury, Md Al Nayem
Chowdhury, Md Al Nayem
Acedera, Jack Dalit
Acedera, Jack Dalit
member
Hsiao, Tzu-Chun (Joann)