Dr. Shih, Chiaho 施嘉和 博士
Ph.D. Massachusetts Institute of Technology
| 1. | Yang CC, Chang CH, Chen HL, Chou MC, Yang CJ, Jhou RS, Huang EY, Li HC, Suen CS, Hwang MJ, Shih C CRM1-spike-mediated nuclear export of hepatitis B virus encapsidated viral RNA. Cell reports 38(10), 110472 (2022) [JCR] [WOS] |
| 2. | Su PY, Yen SB, Yang CC, Chang CH, Lin WC, Shih C Hepatitis B virus virion secretion is a CRM1-spike-mediated late event. Journal of biomedical science 29(1), 44 (2022) [JCR] [WOS] |
| 3. | Chang CH, Chou SF, Shih C A nuanced role of the small loop of hepatitis B virus small envelope protein in virion morphogenesis and secretion. Journal of biomedical science 28(1), 82 (2021) [JCR] [WOS] |
| 4. | Lin Yu-Li, Shih Chiaho, Cheng Pei-Yun, Chin Chiao-Li, Liou An-Ting, Lee Po-Yi, Chiang Bor-Luen A Polysaccharide Purified From Ganoderma lucidum Acts as a Potent Mucosal Adjuvant That Promotes Protective Immunity Against the Lethal Challenge With Enterovirus A71 Frontiers in Immunology 11, 561758 (2020) [JCR] [WOS] |
| 5. | Chang CS, Liao CC, Liou AT, Chou YC, Yu YY, Lin CY, Lin JS, Suen CS, Hwang MJ, Shih C Novel Naturally Occurring Mutations of Enterovirus 71 Associated With Disease Severity. Frontiers in microbiology 11, 610568 (2020) [JCR] [WOS] |
| 6. | Shih C, Wu SY, Chou SF, Yuan TT Virion Secretion of Hepatitis B Virus Naturally Occurring Core Antigen Variants. Cells 10(1) (2020) [JCR] [WOS] |
| 7. | Liou, A., Liao, C., Chou, S., Chang, Y.S., Chang, C.S., and (Shih C*). Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model. Journal of Biomedical Science 26(1), 93 (2019-11) [JCR] [WOS] |
| 8. | Wu SY, Chang YS, Chu TH, and (Shih C*) Persistence of hepatitis B virus DNA and the tempos between virion secretion and genome maturation in a mouse model JOURNAL OF VIROLOGY 93(22): e01001-19 (2019-11) [JCR] [WOS] |
| 9. | Chang CS, Liao CC, Liou AT, Chang YS, Chang YT, Tzeng BH, Chen CC, (Shih C*) Enterovirus 71 targets the cardiopulmonary system in a robust oral infection mouse model Scientific Reports 9, 11108 (2019-07-31) [JCR] [WOS] |
| 10. | (Shih C*), Liao CC, Chang YS, Wu SY, Chang CS, Liou AT Immunocompetent and Immunodeficient Mouse Models for Enterovirus 71 Pathogenesis and Therapy. Viruses 10(12), 674 (2018-12) [JCR] [WOS] |
| 11. | Chen HL, Su PY, Kuo SC, Lauderdale TY, (Shih C*) Adding a C-terminal Cysteine (CTC) Can Enhance the Bactericidal Activity of Three Different Antimicrobial Peptides. Frontiers IN Microbiology 9, 1440 (2018-06) [JCR] [WOS] |
| 12. | (Chiaho Shih*), Ching-Chun Yang, Gansukh Choijilsuren, Chin-Hsu Chang, and An-Ting Liou Hepatitis B Virus TRENDS IN MICROBIOLOGY 26(4), 386-387 (2018-04) [JCR] [WOS] |
| 13. | Huang AM, Lin KW, Lin WH, Wu LH, Chang HC, Ni C, Wang DL, Hsu HY, Su CL, (Shih C*). 1-Hydroxy-3-[(E)-4-(piperazine-diium)but-2-enyloxy]-9,10-anthraquinone ditrifluoroactate induced autophagic cell death in human PC3 cells CHEMICO-BIOLOGICAL INTERACTIONS 281, 60-68 (2018) [JCR] [WOS] |
| 14. | Choijilsuren G, Jhou RS, Chou SF, Chang CJ, Yang HI, Chen YY,Chuang WL,Yu ML, (Shih C*) Heparin at physiological concentration can enhance PEG-free in vitro infection with human hepatitis B virus. Scientific Reports 7(1), 14461 (2017-10) [JCR] [WOS] |
| 15. | Yang CC, Li HC, (Shih C*) A Homokaryon Assay for Nucleocytoplasmic Shuttling Activity of HBV Core Protein. Methods in Molecular Biology 1540, 53-58 (2017-01) [JCR] [WOS] |
| 16. | Su PY, Yang CJ, Chu TH, Chang CH, Chiang C, Tang FM, Lee CY, (Shih C*) HBV maintains electrostatic homeostasis by modulating negative charges from phosphoserine and encapsidated nucleic acids Scientific Reports 6, 38959-1-38959-17 (2016-12) [JCR] [WOS] |
| 17. | Chen HL, Su PY, and (Shih C*) Improvement of in vivo antimicrobial activity of HBcARD peptides by D-arginine replacement APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 100(21), 9125-9132 (2016-11) [JCR] [WOS] |
| 18. | Huang JY, Chen HL, and (Shih C*) MicroRNA miR-204 and miR-1236 inhibit hepatitis B virus replication via two different mechanisms Scientific Reports 6, 34740-34740 (2016-10) [JCR] [WOS] |
| 19. | (Shih C*), Chou SF, Yang CC, Huang JY, Choijilsuren G, Jhou RS Control and Eradication Strategies of Hepatitis B Virus TRENDS IN MICROBIOLOGY 24, 739-749 (2016-09) [JCR] [WOS] |
| 20. | Liou AT, Wu SY, Liao CC, Chang YS, Chang CS, (Shih C*) A new animal model containing human SCARB2 and lacking stat-1 is highly susceptible to EV71. Scientific Reports 6, 31151-31151 (2016-08) [JCR] [WOS] |
| 21. | Chou SF, Tsai ML, Huang JY, Chang YS, and (Shih C*) The dual role of an ESCRT-0 component HGS in HBV transcription and naked capsid secretion PLoS Pathogens 11(10), e1005123-e1005123 (2015-10) [JCR] [WOS] |
| 22. | Huang MT, Liu WL, Lu CW, Huang JJ, Chuang HL, Huang YT, Hong JH, Liu P, Han DS, Chiang BL, (Shih C), Chen PJ, Chen DS Feedback regulation of IFN-alpha/beta signaling by Axl receptor tyrosine kinase modulates HBV immunity. European journal of immunology 45, 1696-1705 (2015-03) [JCR] [WOS] |
| 23. | Huang JY, Chou SF, Lee JW, Chen HL, Chen CM, Tao MH, (Shih C*) MicroRNA-130a can inhibit hepatitis B virus replication via targeting PGC1alpha and PPARgamma. RNA 21, 385-400 (2015-03) [JCR] [WOS] |
| 24. | Liao CC, Liou AT, Chang YS, Wu SY, Chang CS, Lee CK, Kung JT, Tu PH, Yu YY, Lin CY, Lin JS, (Shih C*) Immunodeficient mouse models with different disease profiles by in vivo infection with the same clinical isolate of enterovirus 71. Journal of Virology 88(21), 12485-12499 (2014-11) [JCR] [WOS] |
| 25. | Yang CC, Huang EY, Li HC, Su PY, (Shih C*) Nuclear export of human hepatitis B virus core protein and pregenomic RNA depends on the cellular NXF1-p15 machinery. PLoS One 9(10), e106683-e106683 (2014-10) [JCR] [WOS] |
| 26. | Chu TH, Liou AT, Su PY, Wu HN, and (Shih C)* Nucleic Acid Chaperone Activity Associated with the ARD Domain of Human Hepatitis B Virus Core Protein JOURNAL OF VIROLOGY 88(5), 2530-2543 (2014-03) [JCR] [WOS] |
| 27. | Yu X, Jin L, Jih J, (Shih, C) and Zhou H* 3.5Å cryoEM structure of hepatitis B virus core assembled from full-length core protein PLoS One 8(9), e69729 (2013-09) [JCR] [WOS] |
| 28. | Chen HL, Su PY, Chang YS, Wu SY, Liao YD, Yu HM, Lauderdale TL, Chang KC, (Shih C)* Identification of a novel antimicrobial peptide from human hepatitis B virus core protein arginine-rich domain (ARD) PLoS Pathogens 9(6), e1003425 (2013-06) [JCR] [WOS] |
| 29. | Chen HL, Huang JY, Chen CM, Chu TH, (Shih C*) MicroRNA-22 can reduce parathymosin expression in transdifferentiated hepatocytes. PLoS One 7(4), e34116-e34116 (2012-04) [JCR] [WOS] |
| 30. | Chen CC, Chang CM, Sun CP, Yu CP, Wu PY, Jeng KS, Hu CP, Chen PJ, Wu JC, (Shih C), Gershwin ME, Tao MH Use of RNA interference to modulate liver adenoma development in a murine model transgenic for hepatitis B virus. GENE THERAPY 19, 25-33 (2012-01) [JCR] [WOS] |
| 31. | Wang CH, Davamani F, Sue SC, Lee SC, Wu PL, Tang FM, (Shih C), Huang TH, Wu WG Cell surface heparan sulfates mediated internalization of PWWP/HATH domain of HDGF via macropinocytosis to fine-tune cell signaling process involved in and its effect on fibroblast cell migration Biochem. J. 433(1), 127-138 (2011-01) [JCR] [WOS] |
| 32. | Li HC, Huang EY, Su PY, Wu SY, Yang CC, Lin YS, Chang WC, and (Shih C*) Nuclear Export and Import of Human Hepatitis B Virus Capsid Protein and Particles PLoS Pathogens 6(10), e1001162 (2010-10) [JCR] [WOS] |
| 33. | Liu S, He J, (Shih C), Li K, Dai A, Zhou ZH, Zhang J Structural comparisons of hepatitis B core antigen particles with different C-terminal lengths. VIRUS RESEARCH 149, 241-244 (2010-05) [JCR] [WOS] |
| 34. | Shih HH, (Shih C), Wang HW, Su CW, Sheen IJ, Wu JC Pro-205 of large hepatitis delta antigen and Pro-62 of major hepatitis B surface antigen influence the assembly of different genotypes of hepatitis D virus. JOURNAL OF GENERAL VIROLOGY 91, 1004-1012 (2010-04) [JCR] [WOS] |
| 35. | Chua PK, Tang FM, Huang JY, Suen CS, (Shih C*) Testing the balanced electrostatic interaction hypothesis of hepatitis B virus DNA synthesis by using an in vivo charge rebalance approach. Journal of Virology 84, 2340-2351 (2010-03) [JCR] [WOS] |
| 36. | Newman M, Chua PK, Tang FM, Su PY, and (Shih C*) Testing an Electrostatic Interaction Hypothesis of Hepatitis B Virus Capsid Stability Using an In Vitro Capsid Disassembly/Reassembly System Journal of Virology 83, 10616-10626 (2009-10) [JCR] [WOS] |
| 37. | (Chiaho Shih*) Functional Significance of Naturally Occurring Hepatitis B Virus Variants. Human Virus Guides- Human Hepatitis B Viruses 23-41 (2008) [JCR] [WOS] |
| 38. | Pong Kian Chua, Min-Hui Lin and C. Shih Potent Inhibition of Human Hepatitis B Virus Replication by a Host Factor Vps4 Virology 354, 1月6日 (2006-10) [JCR] [WOS] |
| 39. | Pong Kian Chua, Robert Yung-Liang Wang, Min-Hui Lin, Tetsuya Masuda, Fat-Moon Suk and C. Shih Reduced Secretion of Virions and HBsAg of an HBV Variant Correlates with the Accumulation of the Small S Envelope Protein in ER/Golgi Journal of Virology 79, 13483-13496 (2005-11) [JCR] [WOS] |
| 40. | Robert Yung-Liang Wang, Chia-Ning Shen, Min-Hui Lin, David Tosh and C. Shih Hepatocyte-like Cells Transdifferentiated from Pancreatic Origin can Support Replication of Hepatitis B Virus Journal of Virology 79, 13116-13128 (2005-10) [JCR] [WOS] |
| 41. | Pogam Sophie Le, Chua Pong Kian, Newman Margaret and C. Shih Exposure of RNA Templates and Encapsidation of Spliced Viral RNA are Influenced by the Arginine Rich Domain of Human Hepatitis B Virus Core Antigen (HBcAg 165-173) Journal of Virology 79, 1871-1887 (2005-02) [JCR] [WOS] |
| 42. | B. Ning and C. Shih Nucleolar Localization of Human Hepatitis B Virus Capsid Protein Journal of Virology 78, 13653-13668 (2004-12) [JCR] [WOS] |
| 43. | C. Shih and T. T. Yuan A cis/trans Genetic Test for Pleiotropic Phenotypes Associated with a Frequent Naturally Occurring Mutation at Amino Acid 97 of HBV Core Protein Methods Mol Med 95, 247-257 (2004) [JCR] [WOS] |
| 44. | C. Shih and T. T. Yuan A One-filter-three-probe Assay for Defective Interference (DI) Effects of Naturally-Occurring Core Internal Deletion (CID) Variants of Human Hepatitis B Virus Methods Mol Med 95, 151-163 (2004) [JCR] [WOS] |
| 45. | C. Shih and P. C. Tai Detection of Hypermodified Middle-Envelope (M) Proteins Secreted from Naturally Occurring HBV Variants Containing a preS2 Internal Deletion Methods Mol Med 95, 165-173 (2004) [JCR] [WOS] |
| 46. | M. Newman, F. M. Suk, M. Cajimat, P. K. Chua, and C. Shih Stability and Morphology Comparisons of Self-assembled Virus-Like Particles from Wild Type and Mutant Human Hepatitis B Virus Capsid Proteins Journal of Virology 77, 12950-12960 (2003-12) [JCR] [WOS] |
| 47. | Chua, P.K., Wen, Y.M., and Shih, C. Co-existence of Two Distinct Secretion Mutations (P5T and I97L) in Hepatitis B Virus Core Produces Wild Type Secretion Journal of Virology 77, 7673-7676 (2003-07) [JCR] [WOS] |
| 48. | C. Shih Functional Significance of Naturally Occurring Hepatitis B Virus Variants Human Virus Guides- Human Hepatitis B Viruses 23-41 (2003) [JCR] [WOS] |
| 49. | F. M. Suk, M. H. Lin, M. Newman, S. Pan, S. H. Chen, J. D. Liu and C. Shih Replication Advantage and Host Factor Independent Phenotypes Attributable to a Common Naturally Occurring Capsid Mutation (I97L) in Human Hepatitis B Virus Journal of Virology 76, 12069-12077 (2002-12) [JCR] [WOS] |
| 50. | S. Le Pogam and C. Shih Influence of a putative intermolecular interaction between core and the pre-S1 domain of the large envelope protein on hepatitis B virus secretion Journal of Virology 76, 6510-6517 (2002-07) [JCR] [WOS] |
| 51. | P.-C Tai, F.M. Suk, W. Gerlich, R. Neurath and C. Shih Hypermodification and immune escape of an internally deleted middle envelope (M) protein of frequent and predominant hepatitis B virus variants Virology 292, 44-58 (2002-01) [JCR] [WOS] |
| 52. | G. K. Sahu, P. C. Tai, S. Banerjee, M. H. Lin, B. Tennant, Gerin, J., and Shih, C. Out-of-frame vs. in-frame core internal deletion (CID) variants of human and woodchuck hepatitis B viruses Virology 292, 35-43 (2002-01) [JCR] [WOS] |
| 53. | Le Pogam S, Yuan TT, Sahu GK, Chatterjee S, Shih C Low-level secretion of human hepatitis B virus virions caused by two independent, naturally occurring mutations (P5T and L60V) in the capsid protein. Journal of Virology 74(19), 9099-9105 (2000-10) [JCR] [WOS] |
| 54. | Yuan TT, Shih C A frequent, naturally occurring mutation (P130T) of human hepatitis B virus core antigen is compensatory for immature secretion phenotype of another frequent variant (I97L). Journal of Virology 74(10), 4929-4932 (2000-05) [JCR] [WOS] |
| 55. | Yuan TT, Tai PC, Shih C Subtype-independent immature secretion and subtype-dependent replication deficiency of a highly frequent, naturally occurring mutation of human hepatitis B virus core antigen. Journal of Virology 73(12), 10122-10128 (1999-12) [JCR] [WOS] |
| 56. | Yuan TT, Sahu GK, Whitehead WE, Greenberg R, Shih C The mechanism of an immature secretion phenotype of a highly frequent naturally occurring missense mutation at codon 97 of human hepatitis B virus core antigen. Journal of Virology 73(7), 5731-5740 (1999-07) [JCR] [WOS] |
| 57. | Thomas Ta-Tung Yuan, Min-Hui Lin, Sui Min Qiu and Chiaho Shih* Functional characterization of naturally occurring variants of human hepatitis B virus containing the core internal deletion mutation Journal of Virology 72(3), 2168-2176 (1998-03) [JCR] [WOS] |
| 58. | Yuan TT, Lin MH, Chen DS, Shih C A defective interference-like phenomenon of human hepatitis B virus in chronic carriers. Journal of Virology 72(1), 578-584 (1998-01) [JCR] [WOS] |
| 59. | Tai PC, Banik D, Lin GI, Pai S, Pai K, Lin MH, Yuoh G, Che S, Hsu SH, Chen TC, Kuo TT, Lee CS, Yang CS, Shih C Novel and frequent mutations of hepatitis B virus coincide with a major histocompatibility complex class I-restricted T-cell epitope of the surface antigen. Journal of Virology 71(6), 4852-4856 (1997-06) [JCR] [WOS] |
| 60. | Hosono S, Tai PC, Wang W, Ambrose M, Hwang DG, Yuan TT, Peng BH, Yang CS, Lee CS, Shih C Core antigen mutations of human hepatitis B virus in hepatomas accumulate in MHC class II-restricted T cell epitopes. Virology 212(1), 151-162 (1995-09) [JCR] [WOS] |
| 61. | Yuan TT, Faruqi A, Shih JW, Shih C The mechanism of natural occurrence of two closely linked HBV precore predominant mutations. Virology 211(1), 144-156 (1995-08) [JCR] [WOS] |
| 62. | Wu KJ, Wilson DR, Shih C, Darlington GJ The transcription factor HNF1 acts with C/EBP alpha to synergistically activate the human albumin promoter through a novel domain. The Journal of biological chemistry 269(2), 1177-1182 (1994-01) [JCR] [WOS] |
| 63. | Hosono S, Chou MJ, Lee CS, Shih C Infrequent mutation of p53 gene in hepatitis B virus positive primary hepatocellular carcinomas. Oncogene 8(2), 491-496 (1993-02) [JCR] [WOS] |
| 64. | Faruqi AF, Roychoudhury S, Greenberg R, Israel J, Shih CH Replication-defective missense mutations within the terminal protein and spacer/intron regions of the polymerase gene of human hepatitis B virus. Virology 183(2), 764-768 (1991-08) [JCR] [WOS] |
| 65. | Roychoudhury S, Faruqi AF, Shih C Pregenomic RNA encapsidation analysis of eleven missense and nonsense polymerase mutants of human hepatitis B virus. Journal of virology 65(7), 3617-3624 (1991-07) [JCR] [WOS] |
| 66. | Pei DQ, Shih CH An \"attenuator domain\" is sandwiched by two distinct transactivation domains in the transcription factor C/EBP. Molecular and cellular biology 11(3), 1480-1487 (1991-03) [JCR] [WOS] |
| 67. | Hosono S, Lee CS, Chou MJ, Yang CS, Shih CH Molecular analysis of the p53 alleles in primary hepatocellular carcinomas and cell lines. Oncogene 6(2), 237-243 (1991-02) [JCR] [WOS] |
| 68. | Shih C, Yu MY, Li LS, Shih JW Hepatitis B virus propagated in a rat hepatoma cell line is infectious in a primate model. Virology 179(2), 871-873 (1990-12) [JCR] [WOS] |
| 69. | Ou JH, Bao H, Shih C, Tahara SM Preferred translation of human hepatitis B virus polymerase from core protein- but not from precore protein-specific transcript. Journal of Virology 64(9), 4578-4581 (1990-09) [JCR] [WOS] |
| 70. | Pei DQ, Shih CH Transcriptional activation and repression by cellular DNA-binding protein C/EBP. Journal of Virology 64(4), 1517-1522 (1990-04) [JCR] [WOS] |
| 71. | Roychoudhury S, Shih C cis rescue of a mutated reverse transcriptase gene of human hepatitis B virus by creation of an internal ATG. Journal of Virology 64(3), 1063-1069 (1990-03) [JCR] [WOS] |
| 72. | Shih CH, Li LS, Roychoudhury S, Ho MH In vitro propagation of human hepatitis B virus in a rat hepatoma cell line. Proceedings of the National Academy of Sciences of the United States of America 86(16), 6323-3627 (1989-08) [JCR] [WOS] |
| 73. | Shih C, Burke K, Chou MJ, Zeldis JB, Yang CS, Lee CS, Isselbacher KJ, Wands JR, Goodman HM Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region. Journal of Virology 61(11), 3491-3498 (1987-11) [JCR] [WOS] |
| 74. | He L, Isselbacher KJ, Wands JR, Goodman HM, Shih C, Quaroni A Establishment and characterization of a new human hepatocellular carcinoma cell line. In Vitro-Journal of the Tissue Culture Association 20(6), 493-504 (1984-06) [JCR] [WOS] |
| 75. | de Martinville B, Giacalone J, Shih C, Weinberg RA, Francke U Oncogene from human EJ bladder carcinoma is located on the short arm of chromosome 11. Science 219(4584), 498-501 (1983-02) [JCR] [WOS] |
| 76. | Parada LF, Shih C, Murray M, Weinberg RA The oncogene of a human bladder carcinoma. Progress in nucleic acid research and molecular biology 29, 269-272 (1983) [JCR] [WOS] |
| 77. | Parada LF, Tabin CJ, Shih C, Weinberg RA Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature 297(5866), 474-478 (1982-06) [JCR] [WOS] |
| 78. | Shih C, Weinberg RA Isolation of a transforming sequence from a human bladder carcinoma cell line. Cell 29(1), 161-169 (1982-05) [JCR] [WOS] |
| 79. | Padhy LC, Shih C, Cowing D, Finkelstein R, Weinberg RA Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas. Cell 28(4), 865-871 (1982-04) [JCR] [WOS] |
| 80. | Murray MJ, Shilo BZ, Shih C, Cowing D, Hsu HW, Weinberg RA Three different human tumor cell lines contain different oncogenes. Cell 25(2), 355-361 (1981-08) [JCR] [WOS] |
| 81. | Shih C, Padhy LC, Murray M, Weinberg RA Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts. Nature 290(5803), 261-264 (1981-03) [JCR] [WOS] |
| 82. | Shih C, Shilo BZ, Goldfarb MP, Dannenberg A, Weinberg RA Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. Proceedings of the National Academy of Sciences of the United States of America 76(11), 5714-5718 (1979-11) [JCR] [WOS] |
| 83. | Sun TT, Shih C, Green H Keratin cytoskeletons in epithelial cells of internal organs. Proceedings of the National Academy of Sciences of the United States of America 76(6), 2813-2817 (1979-06) [JCR] [WOS] |
