Dr. Chang, Yi-Cheng 張以承 博士

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Dr. Chang, Yi-Cheng
張以承 博士

Joint Appointment Assistant Research Fellow
合聘助研究員

  • Education:

    M.D. -National Taiwan University

    Ph.D. -Academia Sinica and National Taiwan University Joint Ph.D. Program of Translational Medicine

     

    Position:

    - Associate Professor, Graduate Institute of Medical Genomics and Proteomics, Medical College, National Taiwan University

     

    - Attending Physician, Department of Endocrinology and Metabolism, National Taiwan University Hospital

     

    - Vice CEO, Center for Bariatric and Metabolic Surgery, National Taiwan University Hospital

  • 02-23123456 ext 88656 (NTU) (Lab) (Room No: 343)
  • 02-33936523 (Fax)
  • b83401040@gmail.com
  • Personal Homepage
Specialty:
  • Diabetes and Obesity
  • Genetic epidemiology

RESEARCH

The main research focus of our team are (1) human genetic studies for type 2 diabetes, obesity, and related metabolic traits, especially in East-Asian (2) molecular mechanism by which these genes causes type 2 diabetes and obesity, and (3) preclinical development of small-molecule drug for treating diabetes and obesity. We participates in several international genetic consortium for type 2 diabetes and obesity to identify their susceptible genes. We further validated their function in genetically modified mice model and dissected molecular mechanisms using cell-based models and other techniques. Based on the identified mechanism, we thought to screen small molecules for treatment. Currently, we identify possible targets to treat type 2 diabetes and obesity including enzymes involved in aldehydes metabolism, prostaglandins metabolism, and pentose phosphate pathway.

研究介紹

我們團隊主要研究興趣為(1)人類肥胖與糖尿病(及相關代謝疾病)之遺傳學, 尤其以東亞特有之基因研究為主 (2)人類與小鼠肥胖與糖尿病(及相關代謝疾病)之轉譯醫學。我們參與國際或國內大型遺傳學計畫, 嘗試以遺傳學方法肥胖與糖尿病定位致病基因, 進一步以基因轉殖鼠驗證, 並探討其分子機轉找尋藥物標的, 最後發展小分子藥物, 並期望進入臨床試驗。 目前我們已針對醛類代謝, 前列腺素代謝, 以及磷酸戊糖途徑酵素, 發展小分子藥物以治療肥胖與糖尿病。

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