Dr. Chen, Shih-Yu ’s Lab陳世淯 博士 實驗室


The ability to detect and quantify more types of biomolecules at higher resolutions is crucial for our understanding of biological functions in cells and tissues. For example, single-cell level analyses by fluorescence-based flow cytometry have been a mainstay of immunologic inquiry for nearly four decades. Flow cytometry, which can provide data on ploidy, immuno-phenotype, frequency of cell subsets, expression levels of proteins, and function in single cells, has revolutionized our understanding of cellular individuality in immune function. Our laboratory uses two recently developed technologies, mass cytometry and multiplexed ion beam imaging (MIBI), which facilitate high dimensional (up to 50 parameters), quantitative analysis of molecules at single-cell resolution to enable a deeper understanding of how the immune system interacts with cancer cells. Better understand the underlying mechanism of the dysregulations of immune cells within tumor microenvironment could potentially lead to the design of therapeutic strategies to enhance or reinvigorate the anti-tumor effector functions. 

Dr. Chen, Shih-Yu
陳世淯 博士

Assistant Research Fellow

M.D. National Taiwan University Ph.D. University of California, Davis Research Scientist. Stanford University
  • TEL(office):2652-3994
  • TEL(lab):2652-3589 (Room No: N621)

  • Single cell analysis


Spatial multi-omics analyses of the tumor immune microenvironment
Journal of Biomedical Science, Nov 14, 2022
NK cell receptor and ligand composition influences the clearance of SARS-CoV-2
Journal of Clinical Investigation, Nov 01, 2021
Subcellular localization of biomolecules and drug distribution by high-definition ion beam imaging
Nature Communications, Jul 30, 2021