Dr. Hu, Yu-Feng ’s Lab胡瑜峰 博士 實驗室

RESEARCH

The research interests of our laboratory focus on the translational approach to investigate the mechanisms and discover new therapies for arrhythmias. We bridge the clinical and basic research units to work out the solution by the multidisciplinary collaboration. Several active fields of interests are the creation of biological pacemakers by direct reprogramming for cardiac conduction diseases; translational approaches to study genetics and mechanisms of arrhythmias; artificial intelligence (A.I.) to screen, prevent, and treat arrhythmias. The delivery of the transcription factor (TBX18) reprograms quiescent ventricular cardiomyocytes into beating pacemaker cells. Based on this interesting finding, we have further developed the innovative methods utilizing biomaterials and small molecules to create pacemaker cells in an efficient way. The biological pacemaker cells not only could be used as the alternative to the electronic device, but also applied as an in-vitro engineered cell or tissue model. Clinical genetics screening in the patients with arrhythmias revealed several potential pathogenetic genes for cardiac conduction diseases and arrhythmias. These have been undergoing validation by the arrhythmia models of transgenic mice and human induced pluripotent stem cell-derived cardiomyocytes. To catch up with future trend of biomedical analysis, we use A.I. to explore the clinical databases of arrhythmias including ECGs, genes, and biomarkers. We have come up with several A.I. models to diagnose arrhythmias, rare diseases, and non-invasive monitoring of cardiac phenotypes.

研究介紹

實驗室的主題在研究發現心律失常的新療法和機制。我們將臨床和基礎研究單位聯繫起來,通過多學科合作來尋找解決方案。主要領域包括(1)通過直接細胞編程來創造生物起搏器,以治療心臟傳導疾病; (2) 以合併臨床研究、動物與細胞模式研究心律失常相關基因與機制; (3)以人工智能篩檢,預防和治療心律失常。轉錄因子(TBX18)可將靜止的心室心肌細胞重新編程為可自主放電的起搏細胞。基於這一有趣的發現,我們進一步開發了利用生物材料和小分子的創新方法來製造起搏細胞。生物起搏器細胞不僅可以用作電子設備的替代物,還可以用作體外細胞或組織工程模型。我們於心律失常患者的臨床篩檢發現數個與心臟傳導疾病和心律失常相關的潛在致病基因。通過基因轉殖小鼠和人體誘導的多功能幹細胞衍生心肌細胞的心律失常模型,正進行驗證,期望能找出一些嶄新的疾病機轉與治療藥物。為了趕上生物醫學分析的未來趨勢,我們使用人工智能探索心律失常的臨床數據庫,包括心電圖,基因和生物標誌物。已提出了幾個人工智能模型可用於診斷心律失常,罕見疾病和心臟疾病。

Dr. Hu, Yu-Feng
胡瑜峰 博士

Visiting Associate Research Fellow
客座副研究員


MD. National Cheng-Kung University Ph.D. National Yang-Ming University Post-doctor fellow, Heart Institute, Cedar Sinai Medical Center, USA Attending physician, Division of Cardiology, Taipei Veterans General Hospital.
Specialty:

1. Cardiac arrhythmias

2. Electrophysiology

3. Biological pacemakers

4. Artificial intelligence

HIGHLIGHT 重要成果

Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats
Nature Biomedical Engineering , Nov 22, 2021
ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis
Biochim Biophys Acta Mol Basis Dis. 2021 May 1;1867(5):166088. , May 01, 2021
SVAD: A genetic database curates non-ischemic sudden cardiac death-associated variants
PLoS One. 2020 Aug 19;15(8):e0237731. , Aug 19, 2020

MORE 更多


Top