Dr. Hsieh, Patrick Ching-Ho 's publons link picture

Dr. Hsieh, Patrick Ching-Ho

Distinguished Research Fellow
Division Chief
  • 02-27899170 (Lab) (Room No: N417)
  • 02-27858594 (Fax)

Specialty:
  • Stem cells and regenerative medicine
  • Nanoscience and nanomedicine
  • Translational Research

Education and Positions:
  • M.D. Kaohsiung Medical College
    Ph.D. University of Washington, Seattle (Bioengineering)


  • Personal CV

  • Although the field of cardiac stem cell therapy has significantly advanced over the past years, the premise of regenerating or replacing diseased human myocardium with functional tissue remains unsatisfied. The overall objective of our research is to promote myocardial stem cell therapy through nano-/micro-environmental engineering the intramyocardial stem cell niche for endogenous cardiac stem cells to reactivate, proliferate, differentiate and repopulate the diseased myocardium. Using a cardiac specific inducible Cre-Lox transgenic mouse strain, we have found that an endogenous cardiac stem cell pool may contribute to ~15% of new cardiomyocytes in the peri-infarcted area, saturated as early as within the first 2 weeks after infarction. Accordingly, we focus on (1) animal models to identify the source of this cardiac stem cell pool, and (2) methods to engineer the cardiac nano-/micro-environments for augmenting the regenerative signaling for spontaneous repair. Thus, we employ a team approach which brings together people from a broad variety of backgrounds, including stem biology, engineering and medicine . This combination has allowed us to work together and interact in a way traditionally not available at an individual laboratory or program.

    Our Team
    Team photo

    Journal 121 Book 4

    1. Chen HC, Liu YW, Chang KC, Wu YW, Chen YM, Chao YK, Yu MY, Lundy DJ, CJ, Hsieh ML, Cheng YC, Prajnamitra RP, Lin PJ, Ruan SC, Chen DHK, Shih ESC, Chen KW, Chang SS, Chang CMC, Puntney R, Moy AW, Lee JJ, Wu DC, Hwang MJ, Coonen J, Hacker TA, Yen CLE, Rey FE, Kamp TJ, Hsieh PC* Gut butyrate-producers confer post-infarction cardiac protection Nature Communications 14(1), 7249 (2023-11-09) [JCR] [WOS]
    2. 67.Patrick C Hsieh Metabolic reprogramming in adult cardiomyocytes promotes heart regeneration AHA Scientific Sessions 2023 (2023-11) [JCR] [WOS]
    3. Cheng YC, Hsieh ML, Lin CJ, Chang CMC, Huang CY, Puntney R, Moy AW, Ting CY, Chan DZH, Nicholson MW, Lin PJ, Chen CH, Kim GC, Zhang J, Coonen J, Basu P, Simmons HA, Liu YW, Hacker TA, Kamp TJ, Hsieh PCH* Combined Treatment of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates Circulation 148(18), 1395-1409 (2023-10-31) [JCR] [WOS]
    4. Patrick C Hsieh Metabolic reprogramming in adult cardiomyocytes promotes heart regeneration Cell State Conversions (2023-10) [JCR] [WOS]
    5. Yi-Chan Lee, Yuan-Yuan Cheng, Hsin-Yuan Chien, Shu-Chian Ruan, Po-Ju Lin, Patrick C Hsieh Loss of HMGCS2-mediated Ketogenesis accelerates cardiac aging BCVS 2023 (2023-07) [JCR] [WOS]
    6. Cheng YY, Gregorich Z, Prajnamitra RP, Lundy DJ, Ma TY, Huang YH, Lee YC, Rua SC, Lin JH, Lin PJ, Wen Kuo C, Chen P, Yan YT, Tian R, Kamp TJ, Hsieh PCH* Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration Circulation 146, 1950-1967 (2022-12) [JCR] [WOS]
    7. Yuan-Yuan Cheng, Patrick C.H. Hsieh* HMGCS2-mediated Ketogenesis Induces Adult Cardiomyocyte Dedifferentiation and Enables Cardiac Regeneration AHA Scientific Sessions 2022 (2022-11) [JCR] [WOS]
    8. Yu-Che Cheng, Patrick C.H. Hsieh* Injection Of Human IPSC-derived Cardiac Cells Promote Cardiac Repair After Infarction In Nonhuman Primates AHA Scientific Sessions 2022 (2022-11) [JCR] [WOS]
    9. Hung-Chih Chen, Patrick C.H. Hsieh* Post-infarction cardiac protection by gut butyrate-producers AHA Scientific Sessions 2022 (2022-11) [JCR] [WOS]
    10. Lin CJ, Cheng YC, Chen HC, Chao YK, Nicholson MW, Yen ECL, Kamp TJ, Hsieh PC* Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice Theranostics 12(17), 7319-7334 (2022-10) [JCR] [WOS]

    - POSTDOC -
     Chen, Byron
    Chen, Byron
    - RESEARCH ASSOCIATES -
     Tang, Tony
    Tang, Tony
    Lin, Paul Po-Ju
    Lin, Paul Po-Ju
    Ruan, Papa
    Ruan, Papa
    Lee, Alice
    Lee, Alice
    Chang, Chi-En
    Chang, Chi-En
    Chien , Hsin-Yuan
    Chien , Hsin-Yuan
    Lee, Monica
    Lee, Monica
    Tseng, Ching-Fen
    Tseng, Ching-Fen
    Teng, Irene
    Teng, Irene
    Huang, Yung-Jui Rick
    Huang, Yung-Jui Rick
    Chang, Leo
    Chang, Leo
    Pasaribu, Suminani Novita
    Pasaribu, Suminani Novita
    Luu, Nguyen Ngoc Nguyet
    Luu, Nguyen Ngoc Nguyet
    - STUDENTS -
    Chen, Jui-Shen
    Chen, Jui-Shen
    Lee, Yi-Chan
    Lee, Yi-Chan
    Steward, Theodore
    Steward, Theodore
    - ACADEMIA -
    Cheng, Bill
    Cheng, Bill
    Lundy, David
    Lundy, David
     Hsu, Catherine
    Hsu, Catherine
     Cheng, Yuan-Yuan
    Cheng, Yuan-Yuan
    Lee, Michelle
    Lee, Michelle
    Prajnamitra, Ray Putra
    Prajnamitra, Ray Putra
    - INDUSTRY -
     Huang, Jennifer
    Huang, Jennifer
     Chen, Chien-Hsi
    Chen, Chien-Hsi
    Chen, Jean
    Chen, Jean
    Lee, Desy
    Lee, Desy
    Nicholson, Martin
    Nicholson, Martin
    Beh , Chaw Yee
    Beh , Chaw Yee
    - OVERSEA GRADUATE STUDY -
     Lee, Keng-Jung
    Lee, Keng-Jung
    Chiu, Yueh-Ting (Candice)
    Chiu, Yueh-Ting (Candice)
    Hsu, Chia-Hsin (Cindy)
    Hsu, Chia-Hsin (Cindy)
    Chao, Yu Kai (Kevin)
    Chao, Yu Kai (Kevin)
    You, Min Yi
    You, Min Yi