Dr. Lee, Yu-Ru 's publons link picture

Dr. Lee, Yu-Ru

Assistant Research Fellow

Specialty:
  • Cancer Genetics
  • Cancer Signaling, Post-translational Modifications, Non-coding RNAs
  • Cancer Biology, Targeted/Immunotherapy

Education and Positions:
    • Ph.D., Institute of Molecular Medicine, National Taiwan University College of Medicine
    • Instructor in BIDMC, Harvard Medical School
    • Post-doc in BIDMC, Harvard Medical School

The study of my lab responds to multifaceted focus areas, including ubiquitination, cancer signaling, tumor biology, non-coding RNA, CRISPR screening and targeting therapy/immunotherapy, and addresses one of overarching challenges, to develop effective treatments for the most advanced cancers, including triple negative breast cancer, colon, prostate and liver cancer. We will combine multifaceted cutting-edge approaches, including rigorous biochemical, cellular, genetic engineered mouse models (GEMMs), organoid systems and the new high throughput screening platform by integrating a genome-wide platform on both coding and non-coding CRISPR screening system, which allows us for the first time to assess the functions of novel genes at a genome-wide level. By understanding the mechanistic insights and the control of coding genes/non-coding genes in tumorigenesis will not only help us broaden the knowledge of tumor biology in cancer with various origins, but also lay the framework for either coding based- or RNA based-targeting and immunotherapy cancer interventions. Our ultimate goal is to translate all of these into clinics and, hopefully, these works will hold tremendous promise to human patients.

Our Team
Team photo

Journal 18 Book 0

  1. Xiao X, Shi J, He C, Bu X, Sun Y, Gao M, Xiang B, Xiong W, Dai P, Mao Q, Xing X, Yao Y, Yu H, Xu G, Li S, Ren Y, Chen B, Jiang C, Meng G, (Lee YR), Wei W, Freeman GJ, Xie C, Zhang J ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy. Nature communications 14(1), 2859 (2023) [JCR] [WOS]
  2. Zhang T, Xu D, Trefts E, Lv M, Inuzuka H, Song G, Liu M, Lu J, Liu J, Chu C, Wang M, Wang H, Meng H, Liu H, Zhuang Y, Xie X, Dang F, Guan D, Men Y, Jiang S, Jiang C, Dai X, Liu J, Wang Z, Yan P, Wang J, Tu Z, Babuta M, Erickson E, Hillis AL, Dibble CC, Asara JM, Szabo G, Sicinski P, Miao J, (Lee YR), Pan L, Shaw RJ, Yuan J, Wei W Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. Science (New York, N.Y.) 380(6652), 1372-1380 (2023) [JCR] [WOS]
  3. Zhang T, Xu D, Liu J, Wang M, Duan LJ, Liu M, Meng H, Zhuang Y, Wang H, Wang Y, Lv M, Zhang Z, Hu J, Shi L, Guo R, Xie X, Liu H, Erickson E, Wang Y, Yu W, Dang F, Guan D, Jiang C, Dai X, Inuzuka H, Yan P, Wang J, Babuta M, Lian G, Tu Z, Miao J, Szabo G, Fong GH, Karnoub AE, (Lee YR), Pan L, Kaelin WG Jr, Yuan J, Wei W Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation. Nature cell biology Jul 3., Jul 3.-Jul 3. (2023) [JCR] [WOS]
  4. Lee JD, Paulo JA, Posey RR, Mugoni V, Kong NR, Cheloni G, (Lee YR), Slack FJ, Tenen DG, Clohessy JG, Gygi SP, Pandolfi PP Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia. Nature methods 18(3), 293–302 (2021) [JCR] [WOS]
  5. Kishikawa T, Higuchi H, Wang L, Panch N, Maymi V, Best S, Lee S, Notoya G, Toker A, Matesic LE, Wulf GM, Wei W, Otsuka M, Koike K, Clohessy JG, Lee YR, Pandolfi PP WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models. The Journal of clinical investigation 131(24), e140436-e140436 (2021) [JCR] [WOS]
  6. Lee YR, Pandolfi PP PTEN Mouse Models of Cancer Initiation and Progression. Cold Spring Harbor perspectives in medicine 10(2), a037283-a037283 (2020) [JCR] [WOS]
  7. Lee YR, Yehia L, Kishikawa T, Ni Y, Leach B, Zhang J, Panch N, Liu J, Wei W, Eng C, Pandolfi PP WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition. The New England journal of medicine 382(22), 2103-2116 (2020) [JCR] [WOS]
  8. Zhang J#, Lee YR#, Dang F, Gan W, Menon AV, Katon JM, Hsu CH, Asara JM, Tibarewal P, Leslie NR, Shi Y, Pandolfi PP, Wei W. #Co-first author PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. CANCER DISCOVERY 9(9), 1306-1323 (2019) [JCR] [WOS]
  9. Lee YR, Chen M, Lee JD, Zhang J, Lin SY, Fu TM, Chen H, Ishikawa T, Chiang SY, Katon J, Zhang Y, Shulga YV, Bester AC, Fung J, Monteleone E, Wan L, Shen C, Hsu CH, Papa A, Clohessy JG, Teruya-Feldstein J, Jain S, Wu H, Matesic L, Chen RH, Wei W, Pandolfi PP Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science (New York, N.Y.) 364(6441), aau0159-aau0159 (2019) [JCR] [WOS]
  10. Chen M, Zhang J, Sampieri K, Clohessy JG, Mendez L, Gonzalez-Billalabeitia E, Liu XS, Lee YR, Fung J, Katon JM, Menon AV, Webster KA, Ng C, Palumbieri MD, Diolombi MS, Breitkopf SB, Teruya-Feldstein J, Signoretti S, Bronson RT, Asara JM, Castillo-Martin M, Cordon-Cardo C, Pandolfi PP An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. Nature genetics 50(2), 206-218 (2018) [JCR] [WOS]

- POSTDOC -
Chen, Hsin-Yi
Chen, Hsin-Yi
Lim, Syer Choon
Lim, Syer Choon
- RESEARCH ASSOCIATES -
Hsu, Tsai-Fan
Hsu, Tsai-Fan
Chi, Hsin-Hui
Chi, Hsin-Hui
member
Nguyen, Trang Thi Huyen
- STUDENTS -
Chiu, Chun-Nen
Chiu, Chun-Nen
Ong, Ann-Zhi
Ong, Ann-Zhi
 Ruiz, Liza  González
Ruiz, Liza González
- VISITOR -
Hsiung, En
Hsiung, En
- ALUMNI -
Vu, Thu-Thuy (Julie)
Vu, Thu-Thuy (Julie)
Chang, Chi-Sheng
Chang, Chi-Sheng
Huang, Yao-Shen
Huang, Yao-Shen
member
Lim, Chai Ling
Hu, Chen
Hu, Chen