Dr. Lee, Te-Chang 李德章 博士



  • Discovery of Oral Anticancer 1,2-Bis(hydroxymethyl)benzo[g]pyrrolo[2,1-a]phthalazine Hybrids That Inhibit Angiogenesis and Induce DNA Cross-Links
    Journal of Medicinal Chemistry, Aug 30, 2021
        Designing hybrid molecules with dual functions is one approach to improve the therapeutic efficacy of combination treatm ......
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  • SAHA Overcomes 5-FU Resistance in IFIT2-Depleted Oral Squamous Cell Carcinoma Cells
    Cancers, Nov 26, 2020
    Simple Summary IFIT2 depletion is associated with increased epithelial-mesenchymal transition and metastasis. The main aim of our s ......
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  • Design, synthesis and antitumour evaluation of pyrrolo[1,2-f]-phenanthridine and dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives
    Eur J Med Chem, Jun 23, 2020
    Abstract A series of 1,2-bis(hydroxymethyl)pyrrolo[1,2-f]phenanthridine derivatives and their alkyl (ethyl and isopropyl) carbamates an ......
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  • IFIT1 and IFIT3 promote oral squamous cell carcinoma metastasis and contribute to the anti-tumor effect of gefitinib via enhancing p-EGFR recycling
    oncogene, Jan 09, 2019
    IFIT1 and IFIT3 are abundant products of interferon-stimulating genes. While the importance of IFIT1 and IFIT3 in the prognosis of cancer ha ......
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  • Prognostic Values of EPDR1 Hypermethylation and Its Inhibitory Function on Tumor Invasion in Colorectal Cancer
    Cancers, Oct 22, 2018
    Aberrant DNA methylation is a potential mechanism underlying the development of colorectal cancer (CRC). Thus, identification of prognostic ......
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