Dr. Shih, Hsiu-Ming 施修明 博士



  • Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response.
    EMBO J., Feb 08, 2013
    While numerous small ubiquitin-like modifier (SUMO) conjugated substrates have been identified, very little is known about the cellular sign ......
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  • The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability.
    Oncogene, Dec 03, 2012
    Acute promyelocytic leukemia (APL) is predominantly characterized by chromosomal translocations between the retinoic acid receptor, alpha (R ......
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  • Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis
    Journal of Biological Chemistry, Sep 09, 2011
    We discovered that sumoylation serves as an antiviral mechanism in promoting enterovirus type 71 3C protein ubiquitination and degradatio ......
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  • Structural and Functional Roles of Daxx SIM Phosphorylation in SUMO Paralog-Selective Binding and Apoptosis Modulation.
    Molecular Cell, May 08, 2011
    Small ubiquitin-like modifier (SUMO) conjugation and interaction are increasingly associated with various cellular processes. However, littl ......
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  • Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.
    J Cell Biol., Jun 21, 2010
    Mitotic spindles play essential roles in chromosome congression and segregation during mitosis. Aurora A regulates spindle assembly in part ......
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List of Highlights