Dr. Shih, Hsiu-Ming
施修明 博士
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Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response.
EMBO J., Feb 08, 2013
While numerous small ubiquitin-like modifier (SUMO) conjugated substrates have been identified, very little is known about the cellular sign ......
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The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability.
Oncogene, Dec 03, 2012
Acute promyelocytic leukemia (APL) is predominantly characterized by chromosomal translocations between the retinoic acid receptor, alpha (R ......
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Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis
Journal of Biological Chemistry, Sep 09, 2011
We discovered that sumoylation serves as an antiviral mechanism in promoting enterovirus type 71 3C protein ubiquitination and degradatio ......
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Structural and Functional Roles of Daxx SIM Phosphorylation in SUMO Paralog-Selective Binding and Apoptosis Modulation.
Molecular Cell, May 08, 2011
Small ubiquitin-like modifier (SUMO) conjugation and interaction are increasingly associated with various cellular processes. However, littl ......
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Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.
J Cell Biol., Jun 21, 2010
Mitotic spindles play essential roles in chromosome congression and segregation during mitosis. Aurora A regulates spindle assembly in part ......
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List of Highlights
文件紀錄
Reciprocal regulation of Daxx and PIK3CA promotes colorectal cancer cell growth
Cellular and Molecular Life Sciences Jun 19, 2022
The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis
Scientific Reports Jun 28, 2018
Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction
Scientific Reports Dec 12, 2017
Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression
Oncotarget May 27, 2016
HIC1 interacts with and modulates the activity of STAT3.
Cell Cycle. Jun 21, 2013
Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response.
EMBO J. Feb 08, 2013
The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability.
Oncogene Dec 03, 2012
Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis
Journal of Biological Chemistry Sep 09, 2011
Structural and Functional Roles of Daxx SIM Phosphorylation in SUMO Paralog-Selective Binding and Apoptosis Modulation.
Molecular Cell May 08, 2011
Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.
J Cell Biol. Jun 21, 2010
Role of SUMO-Interacting Motif in Daxx SUMO Modification, Subnuclear Localization, and Repression of Sumoylated Transcription Factors.
Molecular Cell Nov 03, 2006
SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx.
PNAS. Nov 22, 2005
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