Dr. Shih, Hsiu-Ming 's publons link picture

Dr. Shih, Hsiu-Ming

Research Fellow
  • 2789-9060 (Lab) (Room No: N605)
  • 2652-3520 (Office)
  • 2782-7654 (Fax)

Specialty:
  • Protein-protein Interaction & Modification
  • Cancer Cell Signaling
  • Transcriptional Control

Education and Positions:
  • Ph.D. Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota


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Structural and Functional Roles of Daxx SIM Phosphorylation in SUMO Paralog-Selective Binding and Apoptosis Modulation.

Dr. Shih, Hsiu-Ming
Molecular Cell, May 08, 2011

Small ubiquitin-like modifier (SUMO) conjugation and interaction are increasingly associated with various cellular processes. However, little is known about the cellular signaling mechanisms that regulate proteins for distinct SUMO paralog conjugation and interactions. Using the transcriptional coregulator Daxx as a model, we show that SUMO paralog-selective binding and conjugation are regulated by phosphorylation of the Daxx SUMO-interacting motif (SIM). NMR structural studies show thatt Daxx 732E-I-I-V-L-S-D-S-D740