Dr. Shih, Hsiu-Ming
Research Fellow
- 2789-9060 (Lab) (Room No: N605)
- 2652-3520 (Office)
- 2782-7654 (Fax)
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Specialty:
- Protein-protein Interaction & Modification
- Cancer Cell Signaling
- Transcriptional Control
Education and Positions:
Ph.D. Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota
Highlight Detail
Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis
Dr. Shih, Hsiu-Ming
Journal of Biological Chemistry, Sep 09, 2011We discovered that sumoylation serves as an antiviral mechanism in promoting enterovirus type 71 3C protein ubiquitination and degradation. Interestingly, some clinical isolation of EV71 3C sumoylation mutant from patients in Taiwan suffered severe CNS involvement. Our results uncover a previously undescribed cellular regulatory event against EV71 virus replication and host cell apoptosis by sumoylation at 3C protease.