Dr. Tarn, Woan-Yuh 's publons link picture

Dr. Tarn, Woan-Yuh

Distinguished Research Fellow
  • 02-27899015 (Lab) (Room No: N223)
  • 02-26523052
  • 02-27829142 (Fax)

Specialty:

 

  1. mRNA splicing in neuron
  2. translational control in cancer
  3. long non-coding RNA

Education and Positions:
  • Ph.D. National Tsing Hua University
    Postdoc Assoc. Yale University


Highlight Detail
...

RBM4 down-regulates PTB and antagonizes its activity in muscle cell–specific alternative splicing.

Dr. Tarn, Woan-Yuh
JCB., May 02, 2011

Alternative splicing contributes largely to cell differentiation and functional specification. We previously reported that the RNA-binding protein RBM4 antagonizes the activity of splicing factor PTB to modulate muscle cell–specific exon selection of α-tropomyosin. Here we show that down-regulation of PTB and its neuronal analogue nPTB during muscle cell differentiation may involve alternative splicing-coupled nonsense-mediated mRNA decay.