Dr. Tarn, Woan-Yuh 譚婉玉 博士

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hnRNP Q regulates Cdc42-mediated neuronal morphogenesis.

Mol Cell Biol., Apr 09, 2012

The RNA-binding protein hnRNP Q has been implicated in neuronal mRNA metabolism. Here, we show that knockdown of hnRNP Q increased neurite complexity in cultured rat cortical neurons and induced filopodium formation in mouse neuroblastoma cells. Re-expression of hnRNP Q1 in hnRNP Q-depleted cells abrogated the morphological changes of neurites

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