Dr. Tarn, Woan-Yuh 's publons link picture

Dr. Tarn, Woan-Yuh

Distinguished Research Fellow
  • 02-27899015 (Lab) (Room No: N223)
  • 02-26523052
  • 02-27829142 (Fax)
Specialty:

 

  1. mRNA splicing in neuron
  2. translational control in cancer
  3. long non-coding RNA
Education and Positions:

  • Ph.D. National Tsing Hua University
    Postdoc Assoc. Yale University

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Alanine repeats influence protein localization in splicing speckles and paraspeckles.

Dr. Tarn, Woan-Yuh
Nucleic Acids Res., Nov 20, 2014

Mammalian splicing regulatory protein RNA-binding motif protein 4 (RBM4) has an alanine repeat-containing C-terminal domain (CAD) that confers both nuclear- and splicing speckle-targeting activities. Alanine-repeat expansion has pathological potential. Here we show that the alanine-repeat tracts influence the subnuclear targeting properties of the RBM4 CAD in cultured human cells.

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