HIGHLIGHT
重要成果
-
- Optimization and Improvement of qPCR Detection Sensitivity of SARS-CoV-2 in Saliva
- Microbiology Spectrum, Apr 25, 2023
- Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), h ......
- MORE 更多
-
- CpG-adjuvanted stable prefusion SARS-CoV-2 spike protein protected hamsters from SARS-CoV-2 challenge
- Scientific Report , Apr 22, 2021
- Abstract The COVID-19 pandemic presents an unprecedented challenge to global public health. Rapid development and deployment of safe and ......
- MORE 更多
-
- Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice
- PLOS Pathogens, May 11, 2020
- Abstract Zika virus (ZIKV) infection may lead to congenital microcephaly and pregnancy loss in pregnant women. In the context of pregna ......
- MORE 更多
-
- Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections
- Journal of Medicinal Chemistry, Feb 03, 2020
- Emerging and resurging mosquito-borne flaviviruses are an important public health challenge. The increased prevalence of dengue virus (DENV) ......
- MORE 更多
-
- Novel AR-12 derivatives, P12-23 and P12-34, inhibit flavivirus replication by blocking host de novo pyrimidine biosynthesis
- Emerging Microbes & Infections, Nov 21, 2018
- The genus Flavivirus contains many important pathogens, including dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (J ......
- MORE 更多
-
- Inhibition of Japanese encephalitis virus infection by the host zinc-finger antiviral protein
- PLoS pathogens, Jul 17, 2018
- CCCH-type zinc-finger antiviral protein (ZAP) is a host factor that restricts the infection of many viruses mainly through RNA degradation, ......
- MORE 更多
-
- Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission
- PLoS Pathogens, Feb 15, 2018
- Despite the low case fatality, Zika virus (ZIKV) infection has been associated with microcephaly in infants and Guillain-Barré syndro ......
- MORE 更多
-
- Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins.
- PLoS Pathog., Dec 30, 2015
- Mitochondria are highly dynamic subcellular organelles participating in many signaling pathways such as antiviral innate immunity and cell d ......
- MORE 更多
-
- Japanese Encephalitis Virus Nonstructural Protein NS5 Interacts with Mitochondrial Trifunctional Protein and Impairs Fatty Acid β-Oxidation.
- PLoS Pathog., May 27, 2015
- Infection with Japanese encephalitis virus (JEV) can induce the expression of pro-inflammatory cytokines and cause acute encephalitis in hum ......
- MORE 更多
-
- Drug Repurposing of Prochlorperazine Against Dengue Virus Infection.
- J Infect Dis., Jul 14, 2014
- The increasing prevalence of dengue virus (DENV) infection presents serious disease and economic burden in epidemic countries. Despite the c ......
- MORE 更多
