Dr. Lin, Yi-Ling
Distinguished Research Fellow
Division Chief
- 02-2789-9013 (Lab) (Room No: 443)
- 02-2652-3902
- 02-2785-8847 (Fax)
-
Specialty:
- Molecular Virology
- Viral Pathogenesis
- Viral Immunology
Education and Positions:
1992, PhD, University of California, Los Angeles (UCLA), USA
2020 ~ date, CEO, Emerging Infectious Disease Division (EIDD), Biomedical Translation Research Center (BioTReC), Academia Sinica
Contact Information:
Highlight Detail
MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation.
Dr. Lin, Yi-Ling
Nucleic Acids Res., Jan 25, 2013Monocyte chemoattractant protein 1-induced protein 1 (MCPIP1), belonging to the MCPIP family with highly conserved CCCH-type zinc finger and Nedd4-BP1, YacP Nuclease domains, has been implicated in negative regulation of the cellular inflammatory responses. In this report, we demonstrate for the first time that this RNA-binding nuclease also targets viral RNA and possesses potent antiviral activities. Overexpression of the human MCPIP1, but not MCPIP2