Dr. Lin, Yi-Ling ’s Lab林宜玲 博士 實驗室

Drug Repurposing of Prochlorperazine Against Dengue Virus Infection.

The increasing prevalence of dengue virus (DENV) infection presents serious disease and economic burden in epidemic countries. Despite the clinical importance, no DENV vaccine or anti-DENV drug is available. In this study, we found that prochlorperazine (PCZ), a dopamine D2 receptor (D2R) antagonist approved to treat nausea, vomiting and headache in humans, has potent in vitro and in vivo antiviral activity against DENV infection.