Dr. Chau, Lee-Young 趙麗洋 博士



  • Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activity.
    Oncogene., Jun 16, 2014
    Heme oxygenase-1 (HO-1) is a heme-degrading enzyme anchored in the endoplasmic reticulum by a carboxyl-terminal transmembrane segment (TMS). ......
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  • Activator Protein-2α Mediates Carbon Monoxide-Induced Stromal Cell-Derived Factor-1α Expression and Vascularization in Ischemic Heart.
    Arterioscler Thromb Vasc Biol., Feb 07, 2013
    Increased cardiac stromal cell-derived factor-1α (SDF-1α) expression promotes neovascularization and myocardial repair after isc ......
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  • TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation.
    Oncogene., Jun 11, 2012
    The TRC8 gene, which was previously shown to be disrupted by a 3;8 chromosomal translocation in hereditary kidney cancer, encodes for an end ......
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  • Ubiquitin-proteasome system mediates heme oxygenase-1 degradation through endoplasmic reticulum-associated degradation pathway.
    Biochim Biophys Acta., May 21, 2008
    The present study investigated the cellular mechanism underlying the degradation of heme oxygenase-1 (HO-1), an endoplasmic reticulum (ER ......
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  • Systemic Expression of Heme Oxygenase-1 Ameliorates Type 1 Diabetes in Nod.
    Diabetes., Feb 15, 2007
    Heme oxygenase-1 (HO-1) is an enzyme with potent immunoregulatory capacity. To evaluate the effect of HO-1 on autoimmune diabetes, female ......
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