Dr. Chen, Chien-Chang ’s Lab陳建璋 博士 實驗室

The Ca_V3.2 T-Type Ca²⁺ Channel Is Required for Pressure Overload–Induced Cardiac Hypertrophy in Mice.

Voltage-gated T-type Ca²⁺ channels (T-channels) are normally expressed during embryonic development in ventricular myocytes but are undetectable in adult ventricular myocytes. Interestingly, T-channels are reexpressed in hypertrophied or failing hearts. It is unclear whether T-channels play a role in the pathogenesis of cardiomyopathy and what the mechanism might be.Here we show that the a_1H voltage-gated T-type Ca²⁺ channel (Ca_v3.2) is involved...