Dr. Chen, Chien-Chang ’s Lab陳建璋 博士 實驗室


The CaV3.2 T-Type Ca2+ Channel Is Required for Pressure Overload–Induced Cardiac Hypertrophy in Mice.

Circulation Research., Jan 02, 2009

Voltage-gated T-type Ca2+ channels (T-channels) are normally expressed during embryonic development in ventricular myocytes but are undetectable in adult ventricular myocytes. Interestingly, T-channels are reexpressed in hypertrophied or failing hearts. It is unclear whether T-channels play a role in the pathogenesis of cardiomyopathy and what the mechanism might be.Here we show that the a1H voltage-gated T-type Ca2+ channel (Cav3.2) is involved...

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