HIGHLIGHT
重要成果
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- Cav3.2 T-type calcium channel regulates mouse platelet activation and arterial thrombosis
- Journal of thrombosis and haemostasis, Jul 01, 2022
- Background Cav3.2 is a T-type calcium channel that causes low-threshold exocytosis. T-type calcium channe ......
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- Multiomic analyses reveal enriched glycolytic processes in β-myosin heavy chain-expressed cardiomyocytes in early cardiac hypertrophy
- Journal of Molecular and Cellular Cardiology Plus, Jun 27, 2022
- Background Cardiac pressure overload induces cardiac hypertrophy and eventually leads to heart ......
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- The Tarantula Toxin ω-Avsp1a Specifically Inhibits Human CaV3.1 and CaV3.3 via the Extracellular S3-S4 Loop of the Domain 1 Voltage-Sensor
- Biomedicines, May 04, 2022
- Inhibition of T-type calcium channels (CaV3) prevents development of diseases related to cardiovascular and ne ......
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- Neuronal basis for pain-like and anxiety-like behaviors in the central nucleus of the amygdala
- Pain, Mar 18, 2022
- Chronic pain is often accompanied by anxiety and depression disorders. Amygdala nuclei play important roles in ......
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- FAK regulates cardiomyocyte mitochondrial fission and function through Drp1
- FEBS Journal, Nov 05, 2021
- Loss of the mitochondrial fission enzyme dynamin-related protein 1 (Drp1) in cardiomyocytes results in energy shortage a ......
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- Anterior nucleus of paraventricular thalamus mediates chronic mechanical hyperalgesia
- PAIN, May 01, 2019
- Pain-related diseases are the top leading causes of life disability. Identifying brain regions involved in persistent neuronal ......
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- Spinal protein kinase C/extracellular signal-regulated kinase signal pathway mediates hyperalgesia priming
- PAIN, Jan 18, 2018
- Chronic pain can be initiated by one or more acute stimulations to sensitize neurons into the primed state. In the primed state, the basal n ......
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- Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus
- Nature Communications, Oct 10, 2017
- Myocardial infarction is the leading cause of death worldwide. Restoration of blood flow rescues myocardium but also causes ischemia-reperfu ......
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- Three TF Co-expression Modules Regulate Pressure-Overload Cardiac Hypertrophy in Male Mice
- Scientific Reports, Aug 08, 2017
- Pathological cardiac hypertrophy, a dynamic remodeling process, is a major risk factor for heart failure. Although a number of key regulator ......
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- Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.
- PNAS, Apr 28, 2014
- The tracheal cartilage rings are important for protecting and maintaining the airway. However, the chondrogenesis of tracheal cartilage is n ......
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