Dr. Yang, Ruey-Bing (Ray)
Acting Director
Research Fellow
- (02) 2789-9063 (Lab) (Room No: N427)
- (02) 2652-3943
- (02) 2785-8847 (Fax)
-
Specialty:
Signal transduction
Receptor biology
Vascular biology
Education and Positions:
Ph.D., University of Texas Southwestern Medical Center at Dallas
Postdoctoral Fellow, Genentech, Inc.
Highlight Detail
Disruption of Scube2 impairs endochondral bone formation.
Dr. Yang, Ruey-Bing (Ray)
J. Bone Miner. Res., Jan 12, 2015SCUBE2 (signal peptide-CUB-EGF domain-containing protein 2) belongs to a secreted and membrane-tethered multi-domain SCUBE protein family composed of 3 members found in vertebrates and mammals. Recent reports suggested that zebrafish scube2 could facilitate sonic hedgehog (Shh) signaling for proper development of slow muscle. However, whether SCUBE2 can regulate the signaling activity of two other hedgehog ligands (Ihh and Dhh), and the developmental relevance of the SCUBE2-induced hedgehog signaling in mammals remain poorly understood.