Dr. Yang, Ruey-Bing (Ray)
Acting Director
Research Fellow
- (02) 2789-9063 (Lab) (Room No: N427)
- (02) 2652-3943
- (02) 2785-8847 (Fax)
-
Specialty:
Signal transduction
Receptor biology
Vascular biology
Education and Positions:
Ph.D., University of Texas Southwestern Medical Center at Dallas
Postdoctoral Fellow, Genentech, Inc.
Highlight Detail
ATF3-Mediated Epigenetic Regulation Protects against Acute Kidney Injury.
Dr. Yang, Ruey-Bing (Ray)
JASN, Apr 01, 2010A variety of stress stimuli, including ischemia-reperfusion (I/R) injury, induce the transcriptional repressor ATF3 in the kidney. The functional consequences of this upregulation in ATF3 after renal I/R injury are not well understood. Here, we found that ATF3-deficient mice had higher renal I/R-induced mortality, kidney dysfunction, inflammation (number of infiltrating neutrophils, myeloperoxidase activity, and induction of IL-6 and P-selectin), and apoptosis compared with wild-type mice. Furthermore, gene transfer of ATF3 to the kidney rescued the renal I/R-induced injuries in the ATF3-deficient mice.