Dr. Chen, Chinpan
Emeritus Research Fellow
- 02-26523035 (Lab) (Room No: N133)
- 02-27887641 (Fax)
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Specialty:
- Structural Biology
- NMR
Education and Positions:
Ph.D. University of Washington
Highlight Detail
Structural Basis of a Physical Blockage Mechanism for the Interaction of Response Regulator PmrA with Connector Protein PmrD from Klebsiella Pneumoniae.
Dr. Chen, Chinpan
J Biol Chem., Jul 16, 2013In bacteria, the two-component system (TCS) is the most prevalent for sensing and transducing environmental signals into the cell. The PmrA-PmrB TCS, responsible for sensing external stimuli of high Fe3+ and mild acidic conditions, can control the genes involved in lipopolysaccharide modification and polymyxin resistance in pathogens. In Klebsiella pneumoniae, the small basic connector protein PmrD protects phospho-PmrA and prolongs the expression of PmrA-activated genes.