Dr. Huang, Tai-huang

Emeritus Research Fellow
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Specialty:
  • Structural Biology
  • Nuclear Magnetic Resonance Spectroscopy
  • Biophysics

Education and Positions:
  • Ph.D. Brandeis University


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Molecular basis of the recognition of the ap65-1 gene transcription promoter elements by a Myb protein from the protozoan parasite Trichomonas vaginalis

Dr. Huang, Tai-huang
Nucl. Acids Res., Jul 19, 2011

Iron-inducible transcription of the ap65-1 gene in Trichomonas vaginalis involves at least three Myb-like transcriptional factors (tvMyb1, tvMyb2 and tvMyb3) that differentially bind to two closely spaced promoter sites, MRE-1/MRE-2r and MRE-2f. Here, we defined a fragment of tvMyb2 comprising residues 40–156 (tvMyb240–156) as the minimum structural unit that retains near full binding affinity with the promoter DNAs. Like c-Myb in vertebrates, the DNA-free tvMyb240–156 has a flexible and open conformation.