Dr. Huang, Tai-huang
Emeritus Research Fellow
- 886-2-2789-9111(退休人員服務專線)
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Specialty:
- Structural Biology
- Nuclear Magnetic Resonance Spectroscopy
- Biophysics
Education and Positions:
Ph.D. Brandeis University
Highlight Detail
Structural dynamics of the two-component response regulator RstA in recognition of promoter DNA element.
Dr. Huang, Tai-huang
Nucleic Acids Res., Jul 02, 2014The RstA/RstB system is a bacterial two-component regulatory system consisting of the membrane sensor, RstB and its cognate response regulator (RR) RstA. The RstA of Klebsiella pneumoniae (kpRstA) consists of an N-terminal receiver domain (RD, residues 1-119) and a C-terminal DNA-binding domain (DBD, residues 130-236). Phosphorylation of kpRstA induces dimerization, which allows two kpRstA DBDs to bind to a tandem repeat, called the RstA box, and regulate the expression of downstream genes.