Dr. Lim, Carmay ’s Lab林小喬 博士 實驗室

DR_bind: a web server for predicting DNA-binding residues from the protein structure based on electrostatics, evolution and geometry.

DR_bind is a web server that automatically predicts DNA-binding residues, given the respective protein structure based on (i) electrostatics, (ii) evolution and (iii) geometry. In contrast to machine-learning methods, DR_bind does not require a training data set or any parameters. It predicts DNA-binding residues by detecting a cluster of conserved, solvent-accessible residues that are electrostatically stabilized upon mutation to Asp(-)/Glu(-).