Dr. Lim, Carmay ’s Lab林小喬 博士 實驗室


Identification of Labile Zn Sites in Drug-Target Proteins.

J Am Chem Soc., Sep 11, 2013

Labile Zn fingers (Zfs) in proteins contain Zn-bound thiolates that can react with electrophilic agents, causing Zn2+ ejection and protein unfolding. Such labile Zfs have been shown to be Cys4 or Cys3His cores whose Zn-bound Cys have no hydrogen bonds. Our aim here is to identify labile Zfs in proteins that are promising drug targets using these features.

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