Dr. Lim, Carmay ’s Lab林小喬 博士 實驗室

Ion Selectivity Strategies of Sodium Channel Selectivity Filters.

Conspectus Sodium ion channels selectively transport Na+ cations across the cell membrane. These integral parts of the cell machinery are implicated in regulating the cardiac, skeletal and smooth muscle contraction, nerve impulses, salt and water homeostasis, as well as pain and taste perception. Their malfunction often results in various channelopathies of the heart, brain, skeletal muscles, and lung; thus, sodium channels are key drug targets for various disorders including cardiac arrhythmias, heart attack, stroke, migraine, epilepsy, pain, cancer, and autoimmune disorders.