Dr. Lim, Carmay
Emeritus Research Fellow
- +886-2-2789-9043 (Lab) (Room No: N117)
- +886-2-2652-3031 (Office)
- +886-2-2788-7641 (Fax)
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Specialty:
- Computational Biophysics
- Computational Chemistry
- Bioinformatics
Education and Positions:
1984, Ph.D. in Chemical Physics, University of Minnesota, Minneapolis
1979, B.S. in Chemistry, Royal Holloway College, London University
Highlight Detail
Protein/solvent medium effects on Mg(2+)-carboxylate interactions in metalloenzymes.
Dr. Lim, Carmay
J Am Chem Soc, May 12, 2010We employed umbrella sampling molecular dynamics simulations in explicit water to study the binding of the Mg(2+) cofactor to ribonuclease H (RNase H) from three different organisms. We show that the enzyme can differentiate between different Mg(2+)-binding modes that are nearly equally stable by creating a free-energy barrier between