Dr. Chen, Chih-Cheng 陳志成 博士

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HIGHLIGHTS
重要成果

  • Involvement of advillin in somatosensory neuron subtype-specific axon regeneration and neuropathic pain
    PNAS, Aug 20, 2018
    Advillin is a sensory neuron-specific actin-binding protein expressed at high levels in all types of somatosensory neurons in early developm ......
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  • Peripheral sensory neuron injury contributes to neuropathic pain in experimental autoimmune encephalomyelitis
    Scientific Reports, Feb 09, 2017
    Abstract Multiple sclerosis (MS)-induced neuropathic pain deteriorates quality of life in patients but is often refractory to treatment ......
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  • Involvement of TRPV1 and TDAG8 in pruriception associated with noxious acidosis
    Journal of Investigative Dermatology, Aug 24, 2016
    Itch and pain are closely related but distinct sensations. Intradermal injection of acid generates pain in both rodents and humans; however, ......
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  • Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors
    NATURE COMMUNICATIONS, May 10, 2016
    Acid-sensing ion channel 3 (ASIC3) is involved in acid nociception, but its possible role in neurosensory mechanotransduction is disputed. W ......
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  • Targeting ASIC3 for pain, anxiety, and insulin resistance.
    Pharmacol Ther., Dec 30, 2011
    Acid-sensing ion channel 3 (ASIC3) is a sensitive pH sensor predominantly expressed in nociceptors and responds to mild extracellular acidif ......
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