Dr. Chen, Chih-Cheng 陳志成 博士

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An antinociceptive role for substance P in acid-induced chronic muscle pain.

PNAS, Nov 14, 2011

Release of substance P (SP) from nociceptive nerve fibers and activation of its receptor neurokinin 1 (NK1) are important effectors in the transmission of pain signals. Nonetheless, the role of SP in muscle pain remains unknown. Here we show that a single i.m. acid injection in mice lacking SP signaling by deletion of the tachykinin

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