Dr. Chern, Yijuang
Distinguished Research Fellow
- +886227899028 (Lab) (Room No: N333)
- +886226523913 (Office)
- 02-27829143 (Fax)
-
Specialty:
- Signal Transduction
- Gene Regulation
- Neurodegeneration Disease
Education and Positions:
Ph.D. Univ. of Massachusetts
Highlight Detail
Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma.
Dr. Chern, Yijuang
Human Molecular Genetics, Aug 06, 2010Huntington's disease (HD) is a neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat in exon 1 of the huntingtin (HTT) gene. Here, we report that the transcript of the peroxisome proliferator-activated receptor-γ (PPARγ, a transcription factor that is critical for energy homeostasis, was markedly downregulated in multiple tissues of a mouse model (R6/2) of HD and in lymphocytes of HD patients.