Ph.D. Univ. of Massachusetts
Huntington disease (HD) is a dominant neurodegenerative disorder that usually becomes established in middle age. The clinical features include uncontrollable chorea movement, cognitive impairment, and psychiatric syndromes (1). The number of CAG repeats in exon 1 of the huntingtin gene (HTT) of HD patients is known to exceed 35. The expanded CAG repeat is translated into a polyglutamine (polyQ) stretch at the N-terminus of the Htt protein.