Dr. Chern, Yijuang 陳儀莊 博士

Brand

HIGHLIGHT DETAIL
重要成果詳細內容


Lack of Type VI Adenylyl Cyclase (AC6) Leads to Abnormal Sympathetic Tone in Neonatal Mice.

Exp Neurol., May 28, 2013

Visceral functions are regulated by a basal sympathetic nerve discharge (SND), also known as 'sympathetic tone'. We demonstrate herein that AC6 existed in tyrosine hydroxylase-positive rostral ventrolateral medulla neurons in the brainstem. Adenylyl cyclase (AC) assays showed lower basal and pituitary adenylate cyclase-activating peptide-evoked AC activities in the brainstem of AC6-null mice, indicating that AC6 is a prominent AC isozyme in the brainstem. Furthermore, two independent lines of AC6-null mice exhibited a much higher SND,

Journal Link 期刊連結

List of Highlights
文件紀錄

Top