Dr. Chern, Yijuang 陳儀莊 博士

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Activation of AMP- activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.

Hum Mol Genet., Sep 25, 2014

TAR DNA-binding protein-43 (TDP-43) is a nuclear RNA-binding protein involved in many cellular pathways. TDP-43-positive inclusions are a hallmark of amyotrophic lateral sclerosis (ALS). The major clinical presentation of ALS is muscle weakness due to the degeneration of motor neurons. Mislocalization of TDP-43 from the nucleus to the cytoplasm is an early event of ALS.

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