Dr. Chern, Yijuang 陳儀莊 博士

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Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from Huntington's disease iPSCs.

Hum. Mol. Genet., Aug 11, 2015

Huntington's disease (HD) is an autosomal dominant degenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (htt) gene. The most vulnerable brain areas to mutant HTT-evoked toxicity are the striatum and cortex. In spite of the extensive efforts that have been devoted to the characterization of HD pathogenesis, no disease-modifying therapy for HD is currently available.

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