Dr. Chern, Yijuang
Distinguished Research Fellow
- +886227899028 (Lab) (Room No: N333)
- +886226523913 (Office)
- 02-27829143 (Fax)
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Specialty:
- Signal Transduction
- Gene Regulation
- Neurodegeneration Disease
Education and Positions:
Ph.D. Univ. of Massachusetts
Highlight Detail
Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from Huntington's disease iPSCs.
Dr. Chern, Yijuang
Hum. Mol. Genet., Aug 11, 2015Huntington's disease (HD) is an autosomal dominant degenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (htt) gene. The most vulnerable brain areas to mutant HTT-evoked toxicity are the striatum and cortex. In spite of the extensive efforts that have been devoted to the characterization of HD pathogenesis, no disease-modifying therapy for HD is currently available.