Dr. Chern, Yijuang 陳儀莊 博士

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  • A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis
    Movement Disorders, Dec 23, 2021
          Background: Polyglutamine (polyQ) diseases are dominant neurodegenerative diseases caused by an expansi ......
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  • Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases
    Journal of Biomedical Science, Oct 11, 2021
        In modern societies, with an increase in the older population, age-related neurodegenerative diseases have progressively ......
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  • A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS
    Neurobiology of Disease, Oct 08, 2021
        Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons ......
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  • Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative Diseases
    Frontiers in Cellular Neuroscience, Jul 28, 2021
        Impaired energy homeostasis and aberrant translational control have independently been implicated in the pathogenesis of ......
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  • Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy
    Acta Neuropathologica Communications, Jun 25, 2021
    Tau pathology is instrumental in the gradual loss of neuronal functions and cognitive decline in tauopathies, including Alzheimer’s di ......
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