Dr. Huang, Yi-Shuian 黃怡萱 博士

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  • NPGPx modulates CPEB2-controlled HIF-1α RNA translation in response to oxidative stress.
    Nucl. Acids Res., Oct 07, 2015
    Non-selenocysteine-containing phospholipid hydroperoxide glutathione peroxidase (NPGPx or GPx7) is an oxidative stress sensor that modulates ......
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  • Deletion of CPEB3 Enhances Hippocampus-Dependent Memory via Increasing Expressions of PSD95 and NMDA Receptors.
    J Neurosci., Oct 23, 2013
    Long-term memory requires activity-dependent synthesis of plasticity-related proteins (PRPs) to strengthen synaptic efficacy and consequentl ......
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  • NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3.
    Nucleic Acids Res., Jun 22, 2012
    Cytoplasmic polyadenylation element-binding protein (CPEB)3 is a nucleocytoplasm-shuttling RNA-binding protein and predominantly resides in ......
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  • Calpain 2 activated through the NMDA receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons.
    MCB, Jun 18, 2012
    Long-term memory requires the activity-dependent reorganization of synaptic proteome to modulate synaptic efficacy and consequently consolid ......
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  • CPEB2–eEF2 interaction impedes HIF-1α RNA translation
    EMBO J, Dec 09, 2011
    Translation of mRNA into protein proceeds in three phases: initiation, elongation, and termination. Regulated translation allows the prompt ......
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